ID   B2IP34_STRPS            Unreviewed;       740 AA.
AC   B2IP34;
DT   10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT   10-JUN-2008, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=Neuraminidase, putative {ECO:0000313|EMBL:ACB90105.1};
GN   Name=nanC {ECO:0000313|EMBL:ACB90105.1};
GN   OrderedLocusNames=SPCG_0853 {ECO:0000313|EMBL:ACB90105.1};
OS   Streptococcus pneumoniae (strain CGSP14).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=516950 {ECO:0000313|EMBL:ACB90105.1, ECO:0000313|Proteomes:UP000001682};
RN   [1] {ECO:0000313|EMBL:ACB90105.1, ECO:0000313|Proteomes:UP000001682}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGSP14 {ECO:0000313|EMBL:ACB90105.1,
RC   ECO:0000313|Proteomes:UP000001682};
RX   PubMed=19361343; DOI=10.1186/1471-2164-10-158;
RA   Ding F., Tang P., Hsu M.-H., Cui P., Hu S., Yu J., Chiu C.-H.;
RT   "Genome evolution driven by host adaptations results in a more virulent and
RT   antimicrobial-resistant Streptococcus pneumoniae serotype 14.";
RL   BMC Genomics 10:158-158(2009).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
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DR   EMBL; CP001033; ACB90105.1; -; Genomic_DNA.
DR   RefSeq; WP_000739353.1; NC_010582.1.
DR   AlphaFoldDB; B2IP34; -.
DR   SMR; B2IP34; -.
DR   CAZy; CBM40; Carbohydrate-Binding Module Family 40.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   KEGG; spw:SPCG_0853; -.
DR   HOGENOM; CLU_024974_0_0_9; -.
DR   Proteomes; UP000001682; Chromosome.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR002860; BNR_rpt.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR004124; Glyco_hydro_33_N.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR023364; Trans_sialidase_dom3.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF19; SIALIDASE; 1.
DR   Pfam; PF02012; BNR; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF02973; Sialidase; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   3: Inferred from homology;
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..740
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002778900"
FT   DOMAIN          98..269
FT                   /note="Glycoside hydrolase family 33 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02973"
FT   DOMAIN          500..703
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
FT   REGION          46..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   740 AA;  82260 MW;  9697B2A39CF98867 CRC64;
     MKKNIKQYVT LGTAVVLSAF VANSVAAQET ETSEVSTPEL VQPVAPTTPI SEVQPKSGNS
     SEVTVQPRTV ETTVKDPSSA TEETPVLEKN NVTLTGGGEN VTNELKDKFT SGDFTVVIKY
     NQSSEKGLQA LFGISNSKPG QQNSYVDVFL RDNGELGMEA RDTSSNKNHL VSRPASVWGK
     YKQEAVTNTV AVVADSVKKT YSLYANGTKV VEKKVDNFLN IKDIKGIDYY MLGGVKRAGK
     TAFGFNGTLE NIKFFNSALD EETVKKMTTN AVTGHLIYTA NDTTGSNYFR IPVLYTFSNG
     RVFSSIDARY GGTHDFLNKI NIATSYSDDN GKTWTKPKLT LAFDDFAPVP LEWPCDVGGR
     DLQISGGATY IDSVIVEKNN KQVLMFADVM PAGVSFREAT RKDSGYKQID GNYYLKLKKQ
     GDTDYNYTIR ENGTVYDDRT NRPTEFSVDK NFGIKQNGNY LTVEQYSVSF KNNKKTEYRN
     GTHVHMNIFY KDALFKVVPT NYIAYISSND HGESWSAPTL LPPIMGLNRN APYLGPGRGI
     IESSTGRILI PSYTGKESAF IYSDDNGASW KVKVVPLPSS WSAEAQFVEL SPGVIQAYMR
     TNNGKIAYLT STDAGTTWSA PEYLKFVSNP SYGTQLSIIN YSQLIDGKKA VILSTPNSTN
     GRKHGQIWIG LINDDNTIDW RYHHDVDYSN YGYSYSTLTE LPNHEIGLMF EKFDSWSRNE
     LHMKNVVPYI TFKIEDLKKN
//