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B2INH7

- FUCI_STRPS

UniProt

B2INH7 - FUCI_STRPS

Protein

L-fucose isomerase

Gene

fucI

Organism
Streptococcus pneumoniae (strain CGSP14)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

    Catalytic activityi

    L-fucopyranose = L-fuculose.UniRule annotation

    Cofactori

    Manganese.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei335 – 3351Proton acceptorUniRule annotation
    Metal bindingi335 – 3351ManganeseUniRule annotation
    Active sitei359 – 3591Proton acceptorUniRule annotation
    Metal bindingi359 – 3591ManganeseUniRule annotation
    Metal bindingi525 – 5251ManganeseUniRule annotation

    GO - Molecular functioni

    1. L-fucose isomerase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-fucose catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism, Fucose metabolism

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciSPNE516950:GI38-2193-MONOMER.
    UniPathwayiUPA00563; UER00624.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
    Alternative name(s):
    6-deoxy-L-galactose isomeraseUniRule annotation
    FucIase
    Gene namesi
    Name:fucIUniRule annotation
    Ordered Locus Names:SPCG_2126
    OrganismiStreptococcus pneumoniae (strain CGSP14)
    Taxonomic identifieri516950 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000001682: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 588588L-fucose isomerasePRO_1000139966Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi516950.SPCG_2126.

    Structurei

    3D structure databases

    ProteinModelPortaliB2INH7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L-fucose isomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2407.
    HOGENOMiHOG000249674.
    KOiK01818.
    OMAiKEGQDYR.
    OrthoDBiEOG6FJNCF.

    Family and domain databases

    Gene3Di3.20.14.10. 1 hit.
    3.40.275.10. 1 hit.
    3.40.50.1070. 1 hit.
    HAMAPiMF_01254. Fucose_iso.
    InterProiIPR004216. Fuc/Ara_isomerase_C.
    IPR015888. Fuc_isomerase_C.
    IPR012888. Fucose_iso_N1.
    IPR005763. Fucose_isomerase.
    IPR009015. Fucose_isomerase_N/cen.
    IPR012889. Fucose_isomerase_N2.
    [Graphical view]
    PfamiPF02952. Fucose_iso_C. 1 hit.
    PF07881. Fucose_iso_N1. 1 hit.
    PF07882. Fucose_iso_N2. 1 hit.
    [Graphical view]
    SUPFAMiSSF50443. SSF50443. 1 hit.
    SSF53743. SSF53743. 1 hit.
    TIGRFAMsiTIGR01089. fucI. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2INH7-1 [UniParc]FASTAAdd to Basket

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    MIQHPRIGIR PTIDGRRQGV RESLEVQTMN MAKSVADLIS STLKYPDGEP    50
    VECVISPSTI GRVPEAAASH ELFKKSNVCA TITVTPCWCY GSETMDMSPD 100
    IPHAIWGFNG TERPGAVYLA AVLASHAQKG IPAFGIYGRD VQEANDTDIP 150
    EDVKEKLLRY ARAALATGLM RDTAYLSMGS VSMGIGGSIV NPDFFQEYLG 200
    MRNESVDMTE FTRRMDRGIY DPEEFERAMV WVKEHIKEGV DRNREDLILS 250
    KEEKEKQWEF VIKMFMIGRD LMVGNPRLAE LGFEEEAVGH HALVAGFQGQ 300
    RQWTDHFPNG DFMETFLNTQ FDWNGIRKPF VFATENDSLN GVSMLFNYLL 350
    TNTPQIFADV RTYWSPEAVE RVTGYTLEGR AAAGFLHLIN SGSCTLDGTG 400
    QATRDGKPVM KPFWELDESE VQAMLENTDF PPANREYFRG GGFSTRFLTK 450
    GDMPVTMVRL NLLKGVGPVL QIAEGYTLEL PEDVHHTLDN RTDPGWPTTW 500
    FAPRLTGKGA FKSVYDVMNN WGANHGAITY GHIGADLITL ASMLRIPVNM 550
    HNVPEEDIFR PKNWSLFGTE DLESADYRAC QLLGPLHK 588
    Length:588
    Mass (Da):65,890
    Last modified:June 10, 2008 - v1
    Checksum:iFA71F53E326CC52F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001033 Genomic DNA. Translation: ACB91378.1.
    RefSeqiYP_001836843.1. NC_010582.1.

    Genome annotation databases

    EnsemblBacteriaiACB91378; ACB91378; SPCG_2126.
    GeneIDi6216773.
    KEGGispw:SPCG_2126.
    PATRICi19680747. VBIStrPne123335_2278.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001033 Genomic DNA. Translation: ACB91378.1 .
    RefSeqi YP_001836843.1. NC_010582.1.

    3D structure databases

    ProteinModelPortali B2INH7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 516950.SPCG_2126.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB91378 ; ACB91378 ; SPCG_2126 .
    GeneIDi 6216773.
    KEGGi spw:SPCG_2126.
    PATRICi 19680747. VBIStrPne123335_2278.

    Phylogenomic databases

    eggNOGi COG2407.
    HOGENOMi HOG000249674.
    KOi K01818.
    OMAi KEGQDYR.
    OrthoDBi EOG6FJNCF.

    Enzyme and pathway databases

    UniPathwayi UPA00563 ; UER00624 .
    BioCyci SPNE516950:GI38-2193-MONOMER.

    Family and domain databases

    Gene3Di 3.20.14.10. 1 hit.
    3.40.275.10. 1 hit.
    3.40.50.1070. 1 hit.
    HAMAPi MF_01254. Fucose_iso.
    InterProi IPR004216. Fuc/Ara_isomerase_C.
    IPR015888. Fuc_isomerase_C.
    IPR012888. Fucose_iso_N1.
    IPR005763. Fucose_isomerase.
    IPR009015. Fucose_isomerase_N/cen.
    IPR012889. Fucose_isomerase_N2.
    [Graphical view ]
    Pfami PF02952. Fucose_iso_C. 1 hit.
    PF07881. Fucose_iso_N1. 1 hit.
    PF07882. Fucose_iso_N2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50443. SSF50443. 1 hit.
    SSF53743. SSF53743. 1 hit.
    TIGRFAMsi TIGR01089. fucI. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant Streptococcus pneumoniae serotype 14."
      Ding F., Tang P., Hsu M.-H., Cui P., Hu S., Yu J., Chiu C.-H.
      BMC Genomics 10:158-158(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CGSP14.

    Entry informationi

    Entry nameiFUCI_STRPS
    AccessioniPrimary (citable) accession number: B2INH7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3