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B2INA6 (THIM2_STRPS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase 2

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase 2
Short name=TH kinase 2
Short name=Thz kinase 2
Gene names
Name:thiM2
Ordered Locus Names:SPCG_0673
OrganismStreptococcus pneumoniae (strain CGSP14) [Complete proteome] [HAMAP]
Taxonomic identifier516950 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Hydroxyethylthiazole kinase 2 HAMAP-Rule MF_00228
PRO_0000383901

Sites

Binding site421Substrate; via amide nitrogen By similarity
Binding site1171ATP By similarity
Binding site1671ATP By similarity
Binding site1941Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
B2INA6 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: BFB3413C1F3BC939

FASTA26829,219
        10         20         30         40         50         60 
MMQALTNPFP IGSSSLIHCM TNEISCEMLA NGILALGCKP VMADDPREVL DFTKQSQALF 

        70         80         90        100        110        120 
INLGHLSAEK EKAIRMAALY ANQSSLPMVV DAVGVTTSSI RKSLVKDLLD YRPTVLKGNM 

       130        140        150        160        170        180 
SEIRSLVGLK HHGVGVDASA KDQETEDLLQ VLKDWCQTYP GMSFLVTGPK DLVVSKNQVA 

       190        200        210        220        230        240 
VLENGCTELD WITGTGDLVG ALTAVFLSQG KTGFEASCLA VSYLNIAAEK IVVQGMGLEE 

       250        260 
FRYQVLNQLS LLRRDENWLD TIKGEAYE 

« Hide

References

[1]"Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant Streptococcus pneumoniae serotype 14."
Ding F., Tang P., Hsu M.-H., Cui P., Hu S., Yu J., Chiu C.-H.
BMC Genomics 10:158-158(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CGSP14.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001033 Genomic DNA. Translation: ACB89925.1.
RefSeqYP_001835390.1. NC_010582.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING516950.SPCG_0673.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB89925; ACB89925; SPCG_0673.
GeneID6217830.
KEGGspw:SPCG_0673.
PATRIC19677546. VBIStrPne123335_0733.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMALPLMATH.
OrthoDBEOG628F8M.
ProtClustDBCLSK559900.

Enzyme and pathway databases

BioCycSPNE516950:GI38-679-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
ProtoNetSearch...

Entry information

Entry nameTHIM2_STRPS
AccessionPrimary (citable) accession number: B2INA6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 10, 2008
Last modified: February 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways