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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Beijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIB 8712)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi559 – 5668GTPUniRule annotation
Nucleotide bindingi606 – 6105GTPUniRule annotation
Nucleotide bindingi660 – 6634GTPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBIND395963:GJA7-1061-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:Bind_1047
OrganismiBeijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIB 8712)
Taxonomic identifieri395963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBeijerinckiaceaeBeijerinckia
Proteomesi
  • UP000001695 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10531053Translation initiation factor IF-2PRO_1000117324Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi395963.Bind_1047.

Structurei

3D structure databases

ProteinModelPortaliB2IIJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini550 – 720171tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni559 – 5668G1By similarity
Regioni584 – 5885G2By similarity
Regioni606 – 6094G3By similarity
Regioni660 – 6634G4By similarity
Regioni696 – 6983G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QHU. Bacteria.
COG0532. LUCA.
HOGENOMiHOG000076907.
KOiK02519.
OMAiNESNGDK.
OrthoDBiPOG091H00EY.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2IIJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESKNSGEN TLSVTPTKTL SLKRPVEAGT VRQSFPHGRS KAVVVEKVKR
60 70 80 90 100
RPIGPGGDGH PAREAAPTPA PAATVTAPPP AQRPAAPNPT AAPTTPPAAA
110 120 130 140 150
VPNVPPPAPR AEVAPPSAQP APAAPTAATP PAQPKAEPVP APIAAQAAPA
160 170 180 190 200
PVPPVPAPSA PVPSTSAAPA APKPAPAPVS QAKPIQTAPV QTAPAAQASA
210 220 230 240 250
SQTTGPRPVA AGPRPATGAA KQATATPQRG AASPAQRPQT GGGQRSGGQQ
260 270 280 290 300
RNQSGGRGGP GRGESGSSRT PTGVVLRSLT DEEREARARA LSGARIREEE
310 320 330 340 350
DRKRAAAEAK AREEREARER EERAAAEARK AEEDARRLQE QEAKRRSEQE
360 370 380 390 400
AKRRLSGGEP APAASPSVAR KPVMTATAAA PAAAAPSGRA AVTDEEETKR
410 420 430 440 450
VIRRPGMPTK VIVPPRPTKG AEPKSRGRLT VATATGGEEE ERTRSVAAFR
460 470 480 490 500
RRQQRLRGHV NEVKEKLSRE VILPETITIQ ELANRMSERG VDVIKLLMKQ
510 520 530 540 550
GQMAKITDVI DADTAQLIAE ELGHTVKRVA ESDVEEGLFD TVDVEEHLVP
560 570 580 590 600
RPPVVTIMGH VDHGKTSLLD AIRHANVVSG EAGGITQHIG AYQITAPNGS
610 620 630 640 650
PITFIDTPGH AAFTAMRARG AKVTDIVVLV VAADDGVMPQ TAEAVAHARA
660 670 680 690 700
AGVPIIVAIN KIDKPDAKPE RIRSELLQYE VQVESLGGDT LEVEVSATKK
710 720 730 740 750
INLDKLLDLI ALQAELLDLK ANPDRAAEGT VIEASLDKGR GPVATVLVQR
760 770 780 790 800
GTLRVGDIIV GGTHWGHVRA LIDDKGATRS EAGPSMPVEV LGFSGSPEAG
810 820 830 840 850
DRVAVVETEA RAREITEYRE RQRREQAAAR GGQARGSLAD MMSQLKNAGR
860 870 880 890 900
KEFPLVIKGD VQGSVEAVVA TLEKLNTDEV AARIIHAGVG GITESDITLA
910 920 930 940 950
QAAGAVVLGF NVRALKEARA LAEQQGIEIR YYNIIYNLVD DVKAAMSGLL
960 970 980 990 1000
APTLREEMLG NAEILEVFNI SKVGKVAGCR VTDGRVERGA HVRLIRDNVV
1010 1020 1030 1040 1050
VHEGKLSTLK RFKDEVKEVV AGQECGMAFE SYQDMRPHDV IECYNVHEIK

RSL
Length:1,053
Mass (Da):111,003
Last modified:June 10, 2008 - v1
Checksum:iB891FD9116619B04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001016 Genomic DNA. Translation: ACB94690.1.
RefSeqiWP_012384047.1. NC_010581.1.

Genome annotation databases

EnsemblBacteriaiACB94690; ACB94690; Bind_1047.
KEGGibid:Bind_1047.
PATRICi21084819. VBIBeiInd21058_1356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001016 Genomic DNA. Translation: ACB94690.1.
RefSeqiWP_012384047.1. NC_010581.1.

3D structure databases

ProteinModelPortaliB2IIJ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi395963.Bind_1047.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB94690; ACB94690; Bind_1047.
KEGGibid:Bind_1047.
PATRICi21084819. VBIBeiInd21058_1356.

Phylogenomic databases

eggNOGiENOG4107QHU. Bacteria.
COG0532. LUCA.
HOGENOMiHOG000076907.
KOiK02519.
OMAiNESNGDK.
OrthoDBiPOG091H00EY.

Enzyme and pathway databases

BioCyciBIND395963:GJA7-1061-MONOMER.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2_BEII9
AccessioniPrimary (citable) accession number: B2IIJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: September 7, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.