B2IHG2 (KHSE_BEII9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Bind_2334

Organism

Beijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIB 8712) [Complete proteome] [HAMAP]

Taxonomic identifier

395963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Beijerinckiaceae › Beijerinckia

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Homoserine kinase HAMAP MF_00301		PRO_1000115423

Sequences

	Sequence		Length	Mass (Da)
	B2IHG2 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 8F183DA8CAE0DB8B	FASTA	321	35,276
	10 20 30 40 50 60 MAVYTHISET DLKTFLASYD IGNALVLKGI AEGVENSNFF LQTERGFFIL TLYEKRVEEK 70 80 90 100 110 120 DLPFFLGLME HLSRRGLNCP QPVHNRSGHA LGRLAGRPAV IVTFLEGVGA DVADARRCAA 130 140 150 160 170 180 VGEALARLHQ AGADFAGKRT NALGLAAWRP LFETVRDRAD TVAPALAATI AEELDFLEAH 190 200 210 220 230 240 WPRALPQGVI HADLFPDNVL FRGETLSGLI DFYFACVDAY AYDIAICLNA WCFEPDLTFN 250 260 270 280 290 300 IGKGLAFFTG YEHVRKLTAE EAAALPVLAR GGALRFALTR LVDWLNVPKG AMVNPKDPLE 310 320 YMGKLAFHQT VGTVRELGLL R

References

[1]

"Complete sequence of chromosome of Beijerinckia indica subsp. indica ATCC 9039." Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., LaButti K., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Dunfield P.F., Dedysh S.N. , Liesack W., Saw J.H., Alam M., Chen Y., Murrell J.C., Richardson P. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 9039 / DSM 1715 / NCIB 8712.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001016 Genomic DNA. Translation: ACB95947.1.
RefSeq	YP_001833436.1. NC_010581.1.
3D structure databases
ProteinModelPortal	B2IHG2.
ModBase	Search...
Protein-protein interaction databases
STRING	B2IHG2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6198647.
GenomeReviews	Gene locus Bind_2334 in contig CP001016_GR.
KEGG	bid:Bind_2334.
PATRIC	21087579. VBIBeiInd21058_2714.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	CLSK2405699.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_BEII9

Accession

Primary (citable) accession number: B2IHG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	June 10, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program