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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Beijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIB 8712)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciBIND395963:GJA7-746-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Bind_0735
OrganismiBeijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIB 8712)
Taxonomic identifieri395963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBeijerinckiaceaeBeijerinckia
ProteomesiUP000001695 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000132472Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi395963.Bind_0735.

Structurei

3D structure databases

ProteinModelPortaliB2IGK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiSMYDGST.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B2IGK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYLPLTPED RTEMLARVGV PSVDALFEDI PAAKRLVELP DLPLHKGELE
60 70 80 90 100
VERWLGRLSA KNLAASAAPF FVGAGAYKHH VPASVDHLIQ RSEFMTSYTP
110 120 130 140 150
YQPEIAQGTL QYVFEFQTQV AALTGMEVAN ASMYDGSTAT GEAVLMAHRL
160 170 180 190 200
TKRGKAILSG GLHPHYAQVV TSQAALTGHD VVVMPPDLQA KEDLVGRLDA
210 220 230 240 250
QTSCLVVQSP DVFGNLRDLE PLAEACRKQG VLLIAVFTEA VSLGLVKAPG
260 270 280 290 300
DMGADIVVGE GQSIGNALNF GGPYVGLFAT RSKYLRQMPG RLCGETLDAD
310 320 330 340 350
GRRGFVLTLS TREQHIRRDK ATSNICTNSG LCCLAFTIHL TLLGEQGLRQ
360 370 380 390 400
LATINHAHAV DLADRLAKVP GVELLNETFF NEFTIRLPGR AEDHVEALAA
410 420 430 440
QGILAGVPVS RLLPGQGCDD LLIIASTEVN SDDDRAALVD ALAKQIA
Length:447
Mass (Da):48,031
Last modified:June 9, 2008 - v1
Checksum:i9D13387FC16ADEC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001016 Genomic DNA. Translation: ACB94385.1.
RefSeqiYP_001831874.1. NC_010581.1.

Genome annotation databases

EnsemblBacteriaiACB94385; ACB94385; Bind_0735.
KEGGibid:Bind_0735.
PATRICi21084143. VBIBeiInd21058_1021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001016 Genomic DNA. Translation: ACB94385.1.
RefSeqiYP_001831874.1. NC_010581.1.

3D structure databases

ProteinModelPortaliB2IGK3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi395963.Bind_0735.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB94385; ACB94385; Bind_0735.
KEGGibid:Bind_0735.
PATRICi21084143. VBIBeiInd21058_1021.

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiSMYDGST.
OrthoDBiEOG6XWV3B.

Enzyme and pathway databases

BioCyciBIND395963:GJA7-746-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Beijerinckia indica subsp. indica ATCC 9039."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., LaButti K., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Dunfield P.F., Dedysh S.N.
    , Liesack W., Saw J.H., Alam M., Chen Y., Murrell J.C., Richardson P.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9039 / DSM 1715 / NCIB 8712.

Entry informationi

Entry nameiGCSPA_BEII9
AccessioniPrimary (citable) accession number: B2IGK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2009
Last sequence update: June 9, 2008
Last modified: March 31, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.