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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Beijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIB 8712)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Bind_0689
OrganismiBeijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIB 8712)
Taxonomic identifieri395963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBeijerinckiaceaeBeijerinckia
Proteomesi
  • UP000001695 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalUniRule annotationAdd BLAST21
Transmembranei72 – 92HelicalUniRule annotationAdd BLAST21
Transmembranei94 – 114HelicalUniRule annotationAdd BLAST21
Transmembranei135 – 155HelicalUniRule annotationAdd BLAST21
Transmembranei167 – 187HelicalUniRule annotationAdd BLAST21
Transmembranei199 – 219HelicalUniRule annotationAdd BLAST21
Transmembranei236 – 256HelicalUniRule annotationAdd BLAST21
Transmembranei263 – 283HelicalUniRule annotationAdd BLAST21
Transmembranei289 – 309HelicalUniRule annotationAdd BLAST21
Transmembranei337 – 357HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000905921 – 360Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST360

Interactioni

Protein-protein interaction databases

STRINGi395963.Bind_0689.

Structurei

3D structure databases

SMRiB2IGF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B2IGF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTWLAEFAV YFTPLNLFRY ITFRTGGAIA TALFFVFFFG PNIIKSLRIK
60 70 80 90 100
QGKGQPIRSD GPQSHLLTKK GTPTMGGLMI LSGLFVSTLL WANLSNHYVW
110 120 130 140 150
VVLWVMLGYG AIGFYDDYLK VTKQTHNGFS GRGRLACEAG VALVACIAMM
160 170 180 190 200
KLGTPHMTSL AFPAVNGYVV DLGLFFLIFG PFVIVASGNA VNLTDGLDGL
210 220 230 240 250
AIVPVMIAAG TFGIIAYLVG NAIYSDYLRI NFVPGAGELA VVSGAVIGAG
260 270 280 290 300
LGFLWFNAPP AQIFMGDTGS LALGGLLGTI AVAIKHEMVL AIVGGLFALE
310 320 330 340 350
TLSVIVQVVS FKLTGKRVFK MAPIHHHFEQ LGWSEPQVVV RFWIIAFVLA
360
LVGLSTLKLR
Length:360
Mass (Da):38,699
Last modified:June 10, 2008 - v1
Checksum:i03BDA2754CBEC807
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001016 Genomic DNA. Translation: ACB94339.1.
RefSeqiWP_012383697.1. NC_010581.1.

Genome annotation databases

EnsemblBacteriaiACB94339; ACB94339; Bind_0689.
KEGGibid:Bind_0689.

Similar proteinsi

Entry informationi

Entry nameiMRAY_BEII9
AccessioniPrimary (citable) accession number: B2IGF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: June 7, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families