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B2IC30 (FTHS_BEII9) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Bind_1654
OrganismBeijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIB 8712) [Complete proteome] [HAMAP]
Taxonomic identifier395963 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBeijerinckiaceaeBeijerinckia

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000146675

Regions

Nucleotide binding63 – 708ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B2IC30 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 34F1E34F948057DE

FASTA55558,602
        10         20         30         40         50         60 
MSSDLEIARA AKLRPIATVA DEAKIPAEAL HSYGLHVAKI DTSLLPKKDR PAKLVLVTAI 

        70         80         90        100        110        120 
NPTPAGEGKT TTTIGLGDAL RRLGKACVIA LREPSLGPCF GTKGGATGGG YAQIVPMERI 

       130        140        150        160        170        180 
NLHLTGDFHA ITSAHNLLAA LIDNHLYWGA EPKIDSRKVA WRRVLDMNDR ALRQIVVGLG 

       190        200        210        220        230        240 
GGGNGYPRET GFDITAASEI MAIFCLSKDL ADLQQRLAQI IVAQDVNKQP VRADALQAVG 

       250        260        270        280        290        300 
AMTVLLKDAL MPNLVQTLEG TPTFVHGGPF ANIAHGCNSV AATLAAMQLG DYVVTEAGFG 

       310        320        330        340        350        360 
ADLGAEKFLD IKCRQAGIAP SAAVIVATAR ALKSHGGVAP ADLNKENLDA LKAGLANLGR 

       370        380        390        400        410        420 
HIANVKKFGL PVVVAINHFL SDTEAEQELI AHTCRDEYGV EAIDCRHWAA GGKGALALAE 

       430        440        450        460        470        480 
KVIALVEGGT AQFKMLYEDT LPLIEKMRRI AQEIYGAADI SLDAKAKKQL ADIEAQGFGH 

       490        500        510        520        530        540 
FPVCVAKTQY SFAADPKLLG APTGHIVPIR EVRLSAGAGF VVMICGDIMT MPGLSRQPAA 

       550 
WKIGLDAQGN IEGLF 

« Hide

References

[1]"Complete sequence of chromosome of Beijerinckia indica subsp. indica ATCC 9039."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., LaButti K., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Dunfield P.F., Dedysh S.N. expand/collapse author list , Liesack W., Saw J.H., Alam M., Chen Y., Murrell J.C., Richardson P.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 9039 / DSM 1715 / NCIB 8712.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001016 Genomic DNA. Translation: ACB95285.1.
RefSeqYP_001832774.1. NC_010581.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING395963.Bind_1654.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB95285; ACB95285; Bind_1654.
GeneID6200473.
KEGGbid:Bind_1654.
PATRIC21086131. VBIBeiInd21058_2002.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAACEEETE.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycBIND395963:GJA7-1678-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_BEII9
AccessionPrimary (citable) accession number: B2IC30
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways