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B2IC30

- FTHS_BEII9

UniProt

B2IC30 - FTHS_BEII9

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Beijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIB 8712)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi63 – 708ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBIND395963:GJA7-1678-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Bind_1654
    OrganismiBeijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIB 8712)
    Taxonomic identifieri395963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBeijerinckiaceaeBeijerinckia
    ProteomesiUP000001695: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Formate--tetrahydrofolate ligasePRO_1000146675Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi395963.Bind_1654.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiACEEETE.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2IC30-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSDLEIARA AKLRPIATVA DEAKIPAEAL HSYGLHVAKI DTSLLPKKDR    50
    PAKLVLVTAI NPTPAGEGKT TTTIGLGDAL RRLGKACVIA LREPSLGPCF 100
    GTKGGATGGG YAQIVPMERI NLHLTGDFHA ITSAHNLLAA LIDNHLYWGA 150
    EPKIDSRKVA WRRVLDMNDR ALRQIVVGLG GGGNGYPRET GFDITAASEI 200
    MAIFCLSKDL ADLQQRLAQI IVAQDVNKQP VRADALQAVG AMTVLLKDAL 250
    MPNLVQTLEG TPTFVHGGPF ANIAHGCNSV AATLAAMQLG DYVVTEAGFG 300
    ADLGAEKFLD IKCRQAGIAP SAAVIVATAR ALKSHGGVAP ADLNKENLDA 350
    LKAGLANLGR HIANVKKFGL PVVVAINHFL SDTEAEQELI AHTCRDEYGV 400
    EAIDCRHWAA GGKGALALAE KVIALVEGGT AQFKMLYEDT LPLIEKMRRI 450
    AQEIYGAADI SLDAKAKKQL ADIEAQGFGH FPVCVAKTQY SFAADPKLLG 500
    APTGHIVPIR EVRLSAGAGF VVMICGDIMT MPGLSRQPAA WKIGLDAQGN 550
    IEGLF 555
    Length:555
    Mass (Da):58,602
    Last modified:June 10, 2008 - v1
    Checksum:i34F1E34F948057DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001016 Genomic DNA. Translation: ACB95285.1.
    RefSeqiWP_012384642.1. NC_010581.1.
    YP_001832774.1. NC_010581.1.

    Genome annotation databases

    EnsemblBacteriaiACB95285; ACB95285; Bind_1654.
    GeneIDi6200473.
    KEGGibid:Bind_1654.
    PATRICi21086131. VBIBeiInd21058_2002.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001016 Genomic DNA. Translation: ACB95285.1 .
    RefSeqi WP_012384642.1. NC_010581.1.
    YP_001832774.1. NC_010581.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 395963.Bind_1654.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB95285 ; ACB95285 ; Bind_1654 .
    GeneIDi 6200473.
    KEGGi bid:Bind_1654.
    PATRICi 21086131. VBIBeiInd21058_2002.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi ACEEETE.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci BIND395963:GJA7-1678-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Beijerinckia indica subsp. indica ATCC 9039."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., LaButti K., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Dunfield P.F., Dedysh S.N.
      , Liesack W., Saw J.H., Alam M., Chen Y., Murrell J.C., Richardson P.
      Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 9039 / DSM 1715 / NCIB 8712.

    Entry informationi

    Entry nameiFTHS_BEII9
    AccessioniPrimary (citable) accession number: B2IC30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3