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B2IB19 (B2IB19_BEII9) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333
Short name=Coprogen oxidase HAMAP MF_00333
Short name=Coproporphyrinogenase HAMAP MF_00333
EC=1.3.3.3 HAMAP MF_00333
Gene names
Name:hemF HAMAP MF_00333
Ordered Locus Names:Bind_0060
OrganismBeijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIB 8712) [Complete proteome] [HAMAP]
Taxonomic identifier395963 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Beijerinckiaceae › Beijerinckia

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333 SAAS SAAS018375

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333 SAAS SAAS018375

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333 SAAS SAAS018375

Subunit structure

Homodimer By similarity. HAMAP MF_00333 SAAS SAAS018375

Subcellular location

Cytoplasm By similarity HAMAP MF_00333.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family. HAMAP MF_00333

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region71 – 8010Important for dimerization By similarity HAMAP MF_00333
Region131 – 1333Substrate binding By similarity HAMAP MF_00333
Region266 – 30136Important for dimerization By similarity HAMAP MF_00333
Region284 – 2896Substrate binding By similarity HAMAP MF_00333

Sites

Active site1291Proton donor By similarity HAMAP MF_00333
Binding site1151Substrate By similarity HAMAP MF_00333
Site1981Important for dimerization By similarity HAMAP MF_00333

Sequences

Sequence LengthMass (Da)Tools
B2IB19 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 60D7BD5DDBB5EDDD

FASTA30133,927
        10         20         30         40         50         60 
MTPSILEACK AKAKPWFESL QDAIIAAFEK IEAEAPGPFL DDQTPAAGRF TKQPWTRKNP 

        70         80         90        100        110        120 
DGEDGGGGFM GLLKGRVFEK AGIHASTVFG RFAPEFASQI PGAEADPRFW ASGLSLIAHP 

       130        140        150        160        170        180 
VNPNVPTVHM NTRFVVTSKG WFGGGADLTP MLDRRRMQND KDAIDFHAAM REACDKHKDV 

       190        200        210        220        230        240 
ADYPRLKDWC DEYFYLKHRN EPRGIGGVFF DYFDCPDETI FDANFAFAQE IGRAFLAIYP 

       250        260        270        280        290        300 
EIVRRNWAQP WTEADRDEQL VRRGRYVEFN LLYDRGTIFG LKTGGNVEAI LSSLPPVVKW 


R

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References

[1]"Complete sequence of chromosome of Beijerinckia indica subsp. indica ATCC 9039."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., LaButti K., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Dunfield P.F., Dedysh S.N. expand/collapse author list , Liesack W., Saw J.H., Alam M., Chen Y., Murrell J.C., Richardson P.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 9039 / DSM 1715 / NCIB 8712.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001016 Genomic DNA. Translation: ACB93719.1.
RefSeqYP_001831208.1. NC_010581.1.

3D structure databases

ProteinModelPortalB2IB19.
ModBaseSearch...

Protein-protein interaction databases

STRINGB2IB19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6200130.
GenomeReviewsGene locus Bind_0060 in contig CP001016_GR.
KEGGbid:Bind_0060.
PATRIC21082669. VBIBeiInd21058_0293.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG631180.
OMAVKAYLLD.
ProtClustDBPRK05330.

Family and domain databases

HAMAPMF_00333. Coprogen_oxidas.
[Tree]
InterProIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
KOK00228.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB2IB19_BEII9
AccessionPrimary (citable) accession number: B2IB19
Entry history
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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