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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Xylella fastidiosa (strain M23)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei75S-adenosyl-L-methionineUniRule annotation1
Binding sitei100S-adenosyl-L-methionineUniRule annotation1
Binding sitei127S-adenosyl-L-methionineUniRule annotation1
Active sitei150By similarity1
Binding sitei150S-adenosyl-L-methionineUniRule annotation1
Binding sitei154SubstrateUniRule annotation1
Binding sitei186SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:XfasM23_1982
OrganismiXylella fastidiosa (strain M23)
Taxonomic identifieri405441 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
Proteomesi
  • UP000001698 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001363751 – 244tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST244

Proteomic databases

PRIDEiB2I9C6

Structurei

3D structure databases

ProteinModelPortaliB2I9C6
SMRiB2I9C6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni223 – 226Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000073968
KOiK03439
OMAiPDPWHKS

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

B2I9C6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNLLSSDGV QVLPRPFTLN ERRREVRSFV LRQGHFTPAQ KRAFDHYWPR
60 70 80 90 100
FGVDFIGQLR DLDVLFGRSA PKVLEVGFGN GAALRFAAQH EPRYDYIGIE
110 120 130 140 150
VYAPGVGRLL NGLAEDGSRH VRLYHYDAVE VLNKEIVDGA LDEIRIYFPD
160 170 180 190 200
PWHKKRHHKR RLIQPLFATL LVRKLRVGGC LHMATDWADY AEQMWDVLDA
210 220 230 240
TPGLVNRAGL RGQVPCPDWR VQTRFERRGQ NLGHRVWNLL YDRV
Length:244
Mass (Da):28,322
Last modified:June 10, 2008 - v1
Checksum:i8C0C67D4A753D01C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001011 Genomic DNA Translation: ACB93381.1
RefSeqiWP_004090474.1, NC_010577.1

Genome annotation databases

EnsemblBacteriaiACB93381; ACB93381; XfasM23_1982
KEGGixfn:XfasM23_1982

Similar proteinsi

Entry informationi

Entry nameiTRMB_XYLF2
AccessioniPrimary (citable) accession number: B2I9C6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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