B2I7N8 (LPXB_XYLF2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	XfasM23_0318

Organism

Xylella fastidiosa (strain M23) [Complete proteome] [HAMAP]

Taxonomic identifier

405441 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xylella › Xylella fastidiosa

Protein attributes

Sequence length	385 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392
Sequence similarities	Belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 385	385	Lipid-A-disaccharide synthase HAMAP-Rule MF_00392		PRO_1000123069

Sequences

	Sequence		Length	Mass (Da)
	B2I7N8 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 1A95C0596A8E0531	FASTA	385	42,557
	10 20 30 40 50 60 MIQAPRIAII AGEASGDHLG AGLIQQLRLH FATAEFIGIG GDMMRSAGCQ TWFDTSELAV 70 80 90 100 110 120 MGLTEVLRHL PRLLKIRREF CKRALAWHPD VLIGIDAPDF NLTVERWFKQ RHIRTVHYVS 130 140 150 160 170 180 PSIWAWREKR AAKIGASVDR VLCLFPMEPP IYARYGIDAR FVGHPMADEI PYQTDRATAR 190 200 210 220 230 240 TALGLPLLSP VLAVLPGSRH SEISQLGNTF LEAAGQLSEH LPGLHVVIPA ANTQCKPLLA 250 260 270 280 290 300 EQLSRSTLPV MHSHLLDSSA RTAMLAADVV LVASGTATLE AMLLKRPMVV AYKVAPLTYR 310 320 330 340 350 360 IVKTLKLLKI NRFALPNILA GEDLVPELIQ KDCTAPALCA ALLDCFKHPQ KVTALQNRYL 370 380 QLHTQLRRNA STRAAEAIAE LLQQR

References

[1]

"Whole genome sequences of two Xylella fastidiosa strains (M12 and M23) causing almond leaf scorch disease in California." Chen J., Xie G., Han S., Chertkov O., Sims D., Civerolo E.L. J. Bacteriol. 192:4534-4534(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: M23.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001011 Genomic DNA. Translation: ACB91766.1.
RefSeq	YP_001829040.1. NC_010577.1.
3D structure databases
ProteinModelPortal	B2I7N8.
ModBase	Search...
Protein-protein interaction databases
STRING	405441.XfasM23_0318.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACB91766; ACB91766; XfasM23_0318.
GeneID	6204147.
KEGG	xfn:XfasM23_0318.
PATRIC	24142495. VBIXylFas85937_0435.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HOG000018003.
KO	K00748.
OMA	PTVWAWR.
ProtClustDB	PRK00025.
Enzyme and pathway databases
UniPathway	UPA00359; UER00481.
Family and domain databases
HAMAP	MF_00392. LpxB.
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. lpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_XYLF2

Accession

Primary (citable) accession number: B2I7N8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	June 10, 2008
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program