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B2I721

- PANC_XYLF2

UniProt

B2I721 - PANC_XYLF2

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Protein

Pantothenate synthetase

Gene

panC

Organism
Xylella fastidiosa (strain M23)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton donorUniRule annotation
Binding sitei62 – 621Beta-alanineUniRule annotation
Binding sitei62 – 621PantoateUniRule annotation
Binding sitei156 – 1561PantoateUniRule annotation
Binding sitei179 – 1791ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 388ATPUniRule annotation
Nucleotide bindingi150 – 1534ATPUniRule annotation
Nucleotide bindingi187 – 1904ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciXFAS405441:GJJI-189-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:XfasM23_0174
OrganismiXylella fastidiosa (strain M23)
Taxonomic identifieri405441 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
ProteomesiUP000001698: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Pantothenate synthetasePRO_1000097130Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi405441.XfasM23_0174.

Structurei

3D structure databases

ProteinModelPortaliB2I721.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiECPIVRE.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

B2I721-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIDTVTDLSR LRGIVADWRR QGLRVALVPT MGNLHAGHFS LVMLARHYAD
60 70 80 90 100
RVVSSVFVNP TQFGPHEDFQ RYPRTPEADM RGLEHVGCDV LWLPSVETMY
110 120 130 140 150
PLGTERTVRL FIPCVSDVLE GTFRPGHFEG VCTVVARLFN QVLPDVAVFG
160 170 180 190 200
KKDYQQLVVI RQMVVDLAFP IEILGGCIVR ESDGLAMSSR NQYLSMQQRP
210 220 230 240 250
QAAEIHRTLI AMRDAVMSGG VHADVEAEAV RRLEAAGFQV DYAVIRLPDL
260 270 280
CEPIDGIVIS QGIALVAARL GNTRLIDNLE F
Length:281
Mass (Da):31,267
Last modified:June 10, 2008 - v1
Checksum:iFC63D171A64729FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001011 Genomic DNA. Translation: ACB91631.1.
RefSeqiYP_001828905.1. NC_010577.1.

Genome annotation databases

EnsemblBacteriaiACB91631; ACB91631; XfasM23_0174.
GeneIDi6204093.
KEGGixfn:XfasM23_0174.
PATRICi24142095. VBIXylFas85937_0239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001011 Genomic DNA. Translation: ACB91631.1 .
RefSeqi YP_001828905.1. NC_010577.1.

3D structure databases

ProteinModelPortali B2I721.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405441.XfasM23_0174.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB91631 ; ACB91631 ; XfasM23_0174 .
GeneIDi 6204093.
KEGGi xfn:XfasM23_0174.
PATRICi 24142095. VBIXylFas85937_0239.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi ECPIVRE.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci XFAS405441:GJJI-189-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequences of two Xylella fastidiosa strains (M12 and M23) causing almond leaf scorch disease in California."
    Chen J., Xie G., Han S., Chertkov O., Sims D., Civerolo E.L.
    J. Bacteriol. 192:4534-4534(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M23.

Entry informationi

Entry nameiPANC_XYLF2
AccessioniPrimary (citable) accession number: B2I721
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3