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B2I6M1 (SPEA_XYLF2) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:XfasM23_0106
OrganismXylella fastidiosa (strain M23) [Complete proteome] [HAMAP]
Taxonomic identifier405441 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella

Protein attributes

Sequence length628 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 628628Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_1000145605

Regions

Region279 – 28911Substrate-binding Potential

Amino acid modifications

Modified residue991N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B2I6M1 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 0E820F250B06A04A

FASTA62869,214
        10         20         30         40         50         60 
MTWSQDLAHK TYSIRHWADG YFEVNDAGHM VVMPLGGDGV RISLPEVVDA ARAAGAKLPL 

        70         80         90        100        110        120 
LLRFPDILGH RLGKLQAAFA QAQSEWEYAG GYTAVYPIKV NQHRGVAGVL ASHQGDGFGL 

       130        140        150        160        170        180 
EAGSKPELMA VLALSRPGGL IVCNGYKDRE YIRLALIGRK LGLKTFIVIE KPSELRMVLE 

       190        200        210        220        230        240 
EAKTLDVLPG LGVRVRLASL GAGKWQNSGG DKAKFGLSPR QVLDVWKVLR GTEYADCLNV 

       250        260        270        280        290        300 
MHFHMGSQIS NVRDIAKGMR EATRYFVELS RLGAKITHVD VGGGLGIDYE GTRSRSDCSI 

       310        320        330        340        350        360 
NYGLQAYASH IVQPLASACE DYDLVPPRIV TECGRAMTAH HAVLIANVTE VEAVPEGRVP 

       370        380        390        400        410        420 
GVCDDEPAVV RHMREIYGEL DARPAIELFY EAQHFHAEGL AAYTLGQIDL VHRARIDDLF 

       430        440        450        460        470        480 
YAISHGVRER LSHEEKSHRP VLDELNERLV DKYFVNFSVF ESIPDVWAIN QIFPIVPIER 

       490        500        510        520        530        540 
LNEVPTRRGV VCDLTCDSDG TVKQYVENES LDSALPLHVL RHGEAYRIGF FLVGAYQEIL 

       550        560        570        580        590        600 
GDIHNLFGDT DAVEVAVDGR GYRIAQQRCG DTTDVMLDYV GYALDEVRRV YAQRIAAAGM 

       610        620 
SAAESKALSD MLEAGLTGYP YLSDVPLE 

« Hide

References

[1]"Whole genome sequences of two Xylella fastidiosa strains (M12 and M23) causing almond leaf scorch disease in California."
Chen J., Xie G., Han S., Chertkov O., Sims D., Civerolo E.L.
J. Bacteriol. 192:4534-4534(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: M23.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001011 Genomic DNA. Translation: ACB91563.1.
RefSeqYP_001828837.1. NC_010577.1.

3D structure databases

ProteinModelPortalB2I6M1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING405441.XfasM23_0106.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB91563; ACB91563; XfasM23_0106.
GeneID6203266.
KEGGxfn:XfasM23_0106.
PATRIC24141911. VBIXylFas85937_0154.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.
OMAIDHYVDG.
OrthoDBEOG676Z0R.

Enzyme and pathway databases

BioCycXFAS405441:GJJI-114-MONOMER.
UniPathwayUPA00186; UER00284.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR01273. speA. 1 hit.
PROSITEPS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPEA_XYLF2
AccessionPrimary (citable) accession number: B2I6M1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: June 11, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways