B2I4P8 (MSRA_XYLF2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Ordered Locus Names:	XfasM23_0908

Organism

Xylella fastidiosa (strain M23) [Complete proteome] [HAMAP]

Taxonomic identifier

405441 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xylella › Xylella fastidiosa

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP-Rule MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular_function	peptide-methionine (S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 216	216	Peptide methionine sulfoxide reductase MsrA HAMAP-Rule MF_01401		PRO_1000145445
Sites
	Active site	54	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2I4P8 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 8EEC6D7B2EE5604F	FASTA	216	23,858
	10 20 30 40 50 60 MVMTIEALKH LGRVDESRVG RTEPLPLDNR HYVNGHPLCD SFPGLALIQF GLGCFWGAER 70 80 90 100 110 120 LFWQLPGVFS TAAGYAGGGV PYPTYREVCS GETGHAEVVL VVYDHTVISF EQLLQTFWES 130 140 150 160 170 180 HDPTQGMRQG NDIGTQYRSV IHCTTSEQYA AASASREVYQ QQLNTAGYTA ITTEILHPAP 190 200 210 PFYYAENEHQ QYLAKHPNGY CGLGGTGVTC AIRLQV

References

[1]

"Whole genome sequences of two Xylella fastidiosa strains (M12 and M23) causing almond leaf scorch disease in California." Chen J., Xie G., Han S., Chertkov O., Sims D., Civerolo E.L. J. Bacteriol. 192:4534-4534(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: M23.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001011 Genomic DNA. Translation: ACB92343.1.
RefSeq	YP_001829617.1. NC_010577.1.
3D structure databases
ProteinModelPortal	B2I4P8.
SMR	B2I4P8. Positions 9-197.
ModBase	Search...
Protein-protein interaction databases
STRING	405441.XfasM23_0908.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACB92343; ACB92343; XfasM23_0908.
GeneID	6203315.
KEGG	xfn:XfasM23_0908.
PATRIC	24143937. VBIXylFas85937_1145.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HOG000263862.
KO	K07304.
OMA	AISTEIE.
ProtClustDB	PRK00058.
Family and domain databases
Gene3D	3.30.1060.10. 1 hit.
HAMAP	MF_01401. MsrA.
InterPro	IPR002569. Met_Sox_Rdtase_MsrA. [Graphical view]
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_XYLF2

Accession

Primary (citable) accession number: B2I4P8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	June 10, 2008
Last modified:	May 1, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program