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B2I4L7

- PUR9_XYLF2

UniProt

B2I4L7 - PUR9_XYLF2

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Xylella fastidiosa (strain M23)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciXFAS405441:GJJI-906-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:XfasM23_0876
    OrganismiXylella fastidiosa (strain M23)
    Taxonomic identifieri405441 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
    ProteomesiUP000001698: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 527527Bifunctional purine biosynthesis protein PurHPRO_1000096109Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi405441.XfasM23_0876.

    Structurei

    3D structure databases

    ProteinModelPortaliB2I4L7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230372.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2I4L7-1 [UniParc]FASTAAdd to Basket

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    MASDFLPVHR ALLSVSDKTG LVELARVLLA YNIELLSTGG TATIIREAGL    50
    PVQDVADLTD FPEMMDGRVK TLHPVVHGGL LGRAGIDDAV MAKHGIAPID 100
    LLIVNLYPFE QITAKKDCTL ADAVDTIDIG GPAMLRSAAK NFARVAVATS 150
    PDQYPDLLAE LQAHHGQLSA EKRFALAVAA FNHVAQYDAA ISNYLSSVSD 200
    MHTTLPLRHE FPTQLNNTFV KMTDLRYGEN PHQSGAFYRD VHPQPGTLAT 250
    FKQLQGKRLS YNNLVDADAA WECVRQFEAP ACVIVKHANP CGVAVGTACS 300
    DAYEAAYATD PTSAFGGIIA FNRTLDAVTM QSILDRQFVE VLIAPYYDAD 350
    ALAYATKKAN VRVLRIPSTG AMNRYDFKRI GSGLLVQSAD SLNIHSGALK 400
    VVTQLAPTYA QQRDLLFAWH VAKYVKSNAI VYAKDNRTIG IGAGQMSRVY 450
    SARIAGIKAA DAHLAVTGSV MASDAFFPFR DGIDAAAATG IKAVIQPGGS 500
    MRDNEVIAAA DEHGIAMVFT GIRHFRH 527
    Length:527
    Mass (Da):56,725
    Last modified:June 10, 2008 - v1
    Checksum:i3265D4F5E6BED741
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001011 Genomic DNA. Translation: ACB92312.1.
    RefSeqiYP_001829586.1. NC_010577.1.

    Genome annotation databases

    EnsemblBacteriaiACB92312; ACB92312; XfasM23_0876.
    GeneIDi6202988.
    KEGGixfn:XfasM23_0876.
    PATRICi24143858. VBIXylFas85937_1106.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001011 Genomic DNA. Translation: ACB92312.1 .
    RefSeqi YP_001829586.1. NC_010577.1.

    3D structure databases

    ProteinModelPortali B2I4L7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405441.XfasM23_0876.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB92312 ; ACB92312 ; XfasM23_0876 .
    GeneIDi 6202988.
    KEGGi xfn:XfasM23_0876.
    PATRICi 24143858. VBIXylFas85937_1106.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230372.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci XFAS405441:GJJI-906-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Whole genome sequences of two Xylella fastidiosa strains (M12 and M23) causing almond leaf scorch disease in California."
      Chen J., Xie G., Han S., Chertkov O., Sims D., Civerolo E.L.
      J. Bacteriol. 192:4534-4534(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M23.

    Entry informationi

    Entry nameiPUR9_XYLF2
    AccessioniPrimary (citable) accession number: B2I4L7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3