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B2I3E1 (NDK_ACIBC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Nucleoside diphosphate kinase

Short name=NDK
Short name=NDP kinase
EC=2.7.4.6
Alternative name(s):
Nucleoside-2-P kinase
Gene names
Name:ndk
Ordered Locus Names:ACICU_00507
OrganismAcinetobacter baumannii (strain ACICU) [Complete proteome] [HAMAP]
Taxonomic identifier405416 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length143 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate By similarity. HAMAP-Rule MF_00451

Catalytic activity

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. HAMAP-Rule MF_00451

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00451

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00451

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00451.

Sequence similarities

Belongs to the NDK family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 143143Nucleoside diphosphate kinase HAMAP-Rule MF_00451
PRO_1000192246

Sites

Active site1171Pros-phosphohistidine intermediate By similarity
Binding site111ATP By similarity
Binding site591ATP By similarity
Binding site871ATP By similarity
Binding site931ATP By similarity
Binding site1041ATP By similarity
Binding site1141ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B2I3E1 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 13CBBCF29538FA8D

FASTA14315,462
        10         20         30         40         50         60 
MAIERTLSIV KPDAVSKNHI GEIFARFEKA GLKIVATKMK HLSQADAEGF YAEHKERGFF 

        70         80         90        100        110        120 
GDLVAFMTSG PVVVSVLEGE NAVLAHREIL GATNPKEAAP GTIRADFAVS IDENAAHGSD 

       130        140 
SVASAEREIA YFFADNEICP RTR 

« Hide

References

[1]"Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group."
Iacono M., Villa L., Fortini D., Bordoni R., Imperi F., Bonnal R.J., Sicheritz-Ponten T., De Bellis G., Visca P., Cassone A., Carattoli A.
Antimicrob. Agents Chemother. 52:2616-2625(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ACICU.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000863 Genomic DNA. Translation: ACC55819.1.
RefSeqYP_001845166.1. NC_010611.1.

3D structure databases

ProteinModelPortalB2I3E1.
SMRB2I3E1. Positions 2-143.
ModBaseSearch...

Protein-protein interaction databases

STRING405416.ACICU_00507.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACC55819; ACC55819; ACICU_00507.
GeneID6235960.
KEGGabc:ACICU_00507.
PATRIC20709790. VBIAciBau103538_0605.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0105.
HOGENOMHOG000224565.
KOK00940.
OMAFRVVAMK.
ProtClustDBPRK00668.

Enzyme and pathway databases

BioCycABAU405416:GI27-528-MONOMER.

Family and domain databases

Gene3D3.30.70.141. 1 hit.
HAMAPMF_00451. NDP_kinase.
InterProIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PANTHERPTHR11349. PTHR11349. 1 hit.
PfamPF00334. NDK. 1 hit.
[Graphical view]
PRINTSPR01243. NUCDPKINASE.
SMARTSM00562. NDK. 1 hit.
[Graphical view]
SUPFAMSSF54919. NDK. 1 hit.
PROSITEPS00469. NDP_KINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDK_ACIBC
AccessionPrimary (citable) accession number: B2I3E1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: May 29, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families