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Reviewed, UniProtKB/Swiss-Prot B2I3E1 (NDK_ACIBC)

Last modified November 3, 2009. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Nucleoside diphosphate kinase
      Short name=NDK
      Short name=NDP kinase
    EC=2.7.4.6
Alternative name(s):
    Nucleoside-2-P kinase
Gene names
Name: ndk
Ordered Locus Names: ACICU_00507
OrganismAcinetobacter baumannii (strain ACICU) [Complete proteome] [HAMAP]
Taxonomic identifier405416 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter

Protein attributes

Sequence length143 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate By similarity.

Catalytic activity

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. HAMAP MF_00451

Cofactor

Magnesium By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the NDK family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 143143Nucleoside diphosphate kinase HAMAP MF_00451
PRO_1000192246

Sites

Active site1171Pros-phosphohistidine intermediate By similarity
Binding site111ATP By similarity
Binding site591ATP By similarity
Binding site871ATP By similarity
Binding site931ATP By similarity
Binding site1041ATP By similarity
Binding site1141ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B2I3E1-1 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 13CBBCF29538FA8D

FASTA14315,462
        10         20         30         40         50         60 
MAIERTLSIV KPDAVSKNHI GEIFARFEKA GLKIVATKMK HLSQADAEGF YAEHKERGFF 

        70         80         90        100        110        120 
GDLVAFMTSG PVVVSVLEGE NAVLAHREIL GATNPKEAAP GTIRADFAVS IDENAAHGSD 

       130        140 
SVASAEREIA YFFADNEICP RTR 

« Hide

References

[1]"Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group."
Iacono M., Villa L., Fortini D., Bordoni R., Imperi F., Bonnal R.J., Sicheritz-Ponten T., De Bellis G., Visca P., Cassone A., Carattoli A.
Antimicrob. Agents Chemother. 52:2616-2625(2008) [PubMed: 18411315] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

CP000863 Genomic DNA. Translation: ACC55819.1.
RefSeqYP_001845166.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID6235960.
GenomeReviewsGene locus ACICU_00507 in contig CP000863_GR.
KEGGabc:ACICU_00507.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMANLTGAIT.

Family and domain databases

HAMAPMF_00451.
[Tree]
InterProIPR001564. Nuc_diP_kinase_core.
[Graphical view]
Gene3DG3DSA:3.30.70.141. NDK. 1 hit.
PANTHERPTHR11349. Nuc_diP_kinase_core. 1 hit.
PfamPF00334. NDK. 1 hit.
[Graphical view]
PRINTSPR01243. NUCDPKINASE.
SMARTSM00562. NDK. 1 hit.
[Graphical view]
PROSITEPS00469. NDP_KINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDK_ACIBC
AccessionPrimary (citable) accession number: B2I3E1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: November 3, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents