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B2I2R9 (HEMH_ACIBC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:ACICU_00392
OrganismAcinetobacter baumannii (strain ACICU) [Complete proteome] [HAMAP]
Taxonomic identifier405416 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Ferrochelatase HAMAP MF_00323
PRO_1000116022

Sites

Metal binding2021Iron By similarity
Metal binding2831Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
B2I2R9 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 60EBEE2A3FCD244E

FASTA33838,276
        10         20         30         40         50         60 
MSFEQKPKVT VILANLGTPD EATVPAVRRF LKQFLSDPRV IEIPKFIWWI ILNLFVLPFR 

        70         80         90        100        110        120 
PKRVAHAYAS VWSTDSPMRE IVFEQTQRVQ AYLERENKQF DLTVLPAMTY GNPGIDAVLE 

       130        140        150        160        170        180 
KLATNPQEHV ILLPLFPQYS ATSTAPLYDA FAKWIPTQRN LPGLTIIKDY YQHPMFIQAL 

       190        200        210        220        230        240 
AESVLAYQEQ HGKPEKLLMS FHGIPQPYAD KGDPYADRCR ITAKLVAEAL HLKDDEWAIS 

       250        260        270        280        290        300 
FQSRFGKQEW VKPYTDQLLQ DWAKQGVKSV QVLSPAFSAD CLETLEELAI QNAELFQQAG 

       310        320        330 
GGSYAYIPAL NSDQAHIDLL AGLVQANLDA LTHTLAHR

« Hide

References

[1]"Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group."
Iacono M., Villa L., Fortini D., Bordoni R., Imperi F., Bonnal R.J., Sicheritz-Ponten T., De Bellis G., Visca P., Cassone A., Carattoli A.
Antimicrob. Agents Chemother. 52:2616-2625(2008) [PubMed: 18411315] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ACICU.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000863 Genomic DNA. Translation: ACC55704.1.
RefSeqYP_001845051.1. NC_010611.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB2I2R9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6236909.
GenomeReviewsGene locus ACICU_00392 in contig CP000863_GR.
KEGGabc:ACICU_00392.
PATRIC20709556. VBIAciBau103538_0490.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMATIEEIGM.
ProtClustDBCLSK2307544.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_ACIBC
AccessionPrimary (citable) accession number: B2I2R9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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