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Protein

3-ketoacyl-CoA thiolase

Gene

fadA

Organism
Acinetobacter baumannii (strain ACICU)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.UniRule annotation

Catalytic activityi

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.UniRule annotation

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei95Acyl-thioester intermediateUniRule annotation1
Active sitei346Proton acceptorUniRule annotation1
Active sitei376Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00659.

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA thiolaseUniRule annotation (EC:2.3.1.16UniRule annotation)
Alternative name(s):
Acetyl-CoA acyltransferaseUniRule annotation
Beta-ketothiolaseUniRule annotation
Fatty acid oxidation complex subunit betaUniRule annotation
Gene namesi
Name:fadAUniRule annotation
Ordered Locus Names:ACICU_00321
OrganismiAcinetobacter baumannii (strain ACICU)
Taxonomic identifieri405416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001860191 – 3903-ketoacyl-CoA thiolaseAdd BLAST390

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB2I2J8.
SMRiB2I2J8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000012239.
KOiK00632.
OMAiCGGTESM.

Family and domain databases

CDDicd00751. thiolase. 1 hit.
Gene3Di3.40.47.10. 2 hits.
HAMAPiMF_01620. FadA. 1 hit.
InterProiView protein in InterPro
IPR012805. FadA.
IPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
PfamiView protein in Pfam
PF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
TIGR02445. fadA. 1 hit.
PROSITEiView protein in PROSITE
PS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

B2I2J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLNPRDVV IVDGVRSAMG KSKNGMFRNV RADSLSAELV RALVARNQFD
60 70 80 90 100
VNEVEDLIWG CVNQTLEQGM NIGRNIGLLA GLPKTVAGQT VNRLCGSSMQ
110 120 130 140 150
AIHTAAAQIA TNQGDIFIIG GVEHMGHVGM MHGIDLNPEA SKHYAKASNM
160 170 180 190 200
MGLTAEMLGR MNGITREEQD AFGVESHRRA WAATQEGRFK NEIIGVEGHD
210 220 230 240 250
ANGFKILCDI DEVIRPDANL EAFKALKPVF DPKGGSVTAA TSSALSDGAS
260 270 280 290 300
AMLLMSAERA QALGLKPRAV IRSMAVAGCD AAIMGYGPVP ATQKALKRAG
310 320 330 340 350
LSIADIQTVE LNEAFAAQGL SVLKGLGLYD KQDIVNLNGG AIALGHPLGC
360 370 380 390
SGARITTTLL NVMEQQDTQI GLATMCIGLG QGIATVIERV
Length:390
Mass (Da):41,088
Last modified:June 10, 2008 - v1
Checksum:iB192B88AA9AF627A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000863 Genomic DNA. Translation: ACC55633.1.
RefSeqiWP_000212712.1. NC_010611.1.

Genome annotation databases

EnsemblBacteriaiACC55633; ACC55633; ACICU_00321.
GeneIDi31350122.
KEGGiabc:ACICU_00321.

Similar proteinsi

Entry informationi

Entry nameiFADA_ACIBC
AccessioniPrimary (citable) accession number: B2I2J8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 10, 2008
Last modified: August 30, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families