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B2I1P1 (PNCB_ACIBC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase

Short name=NAPRTase
EC=6.3.4.21
Gene names
Name:pncB
Ordered Locus Names:ACICU_03580
OrganismAcinetobacter baumannii (strain ACICU) [Complete proteome] [HAMAP]
Taxonomic identifier405416 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity. HAMAP-Rule MF_00570

Catalytic activity

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate. HAMAP-Rule MF_00570

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570

Sequence similarities

Belongs to the NAPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 404404Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570
PRO_1000129458

Sequences

Sequence LengthMass (Da)Tools
B2I1P1 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: E675054A84B7FE9F

FASTA40447,299
        10         20         30         40         50         60 
MSPIIHSLLD TDLYKFTMLQ VVLHKFPQTH SVYHFRCRNL EDTVYPLVDI LDDLNEQLDH 

        70         80         90        100        110        120 
LCNLKYKEDE LQYLRKLRFI KSDFVDYLEL FQLKRRFIHA SIDEEGRLDI RIEGPMVQAM 

       130        140        150        160        170        180 
MFEIFVLAIV NELYFSRIKT DEVWAEGERR LQAKLELIQQ YEKSQQPNDP PFLVSDFGTR 

       190        200        210        220        230        240 
RRYSFEWQKH VVAAFHNTVP NVFRGTSNVL LAKELNITPI GTMAHEFLQA FQALDVRLRD 

       250        260        270        280        290        300 
FQKAALETWV QEYRGDLGIA LTDVVGMDAF LRDFDLYFAK LFDGLRHDSG DPYEWGDKAY 

       310        320        330        340        350        360 
AHYRKLKIDT KTKMLTFSDG LNLPKAWELH QYFKDRFQVS FGIGTNLTND MGQTPLNIVL 

       370        380        390        400 
KLVECNGQSV AKISDSPGKT MTDNDTFLAY LRQVFQIEEL DEAI 

« Hide

References

[1]"Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group."
Iacono M., Villa L., Fortini D., Bordoni R., Imperi F., Bonnal R.J., Sicheritz-Ponten T., De Bellis G., Visca P., Cassone A., Carattoli A.
Antimicrob. Agents Chemother. 52:2616-2625(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ACICU.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000863 Genomic DNA. Translation: ACC58889.1.
RefSeqYP_001848236.1. NC_010611.1.

3D structure databases

ProteinModelPortalB2I1P1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING405416.ACICU_03580.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACC58889; ACC58889; ACICU_03580.
GeneID6236047.
KEGGabc:ACICU_03580.
PATRIC20715903. VBIAciBau103538_3600.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1488.
HOGENOMHOG000284928.
KOK00763.
OMAQAVFHRY.
OrthoDBEOG6X10XB.

Enzyme and pathway databases

BioCycABAU405416:GI27-3654-MONOMER.
UniPathwayUPA00253; UER00457.

Family and domain databases

HAMAPMF_00570. NAPRTase.
InterProIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 1 hit.
TIGRFAMsTIGR01514. NAPRTase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePNCB_ACIBC
AccessionPrimary (citable) accession number: B2I1P1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: June 11, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways