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B2I1P1

- PNCB_ACIBC

UniProt

B2I1P1 - PNCB_ACIBC

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Acinetobacter baumannii (strain ACICU)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciABAU405416:GI27-3654-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:ACICU_03580
    OrganismiAcinetobacter baumannii (strain ACICU)
    Taxonomic identifieri405416 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
    ProteomesiUP000008839: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404Nicotinate phosphoribosyltransferasePRO_1000129458Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi405416.ACICU_03580.

    Structurei

    3D structure databases

    ProteinModelPortaliB2I1P1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284928.
    KOiK00763.
    OMAiQAVFHRY.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2I1P1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPIIHSLLD TDLYKFTMLQ VVLHKFPQTH SVYHFRCRNL EDTVYPLVDI    50
    LDDLNEQLDH LCNLKYKEDE LQYLRKLRFI KSDFVDYLEL FQLKRRFIHA 100
    SIDEEGRLDI RIEGPMVQAM MFEIFVLAIV NELYFSRIKT DEVWAEGERR 150
    LQAKLELIQQ YEKSQQPNDP PFLVSDFGTR RRYSFEWQKH VVAAFHNTVP 200
    NVFRGTSNVL LAKELNITPI GTMAHEFLQA FQALDVRLRD FQKAALETWV 250
    QEYRGDLGIA LTDVVGMDAF LRDFDLYFAK LFDGLRHDSG DPYEWGDKAY 300
    AHYRKLKIDT KTKMLTFSDG LNLPKAWELH QYFKDRFQVS FGIGTNLTND 350
    MGQTPLNIVL KLVECNGQSV AKISDSPGKT MTDNDTFLAY LRQVFQIEEL 400
    DEAI 404
    Length:404
    Mass (Da):47,299
    Last modified:June 10, 2008 - v1
    Checksum:iE675054A84B7FE9F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000863 Genomic DNA. Translation: ACC58889.1.
    RefSeqiYP_001848236.1. NC_010611.1.

    Genome annotation databases

    EnsemblBacteriaiACC58889; ACC58889; ACICU_03580.
    GeneIDi6236047.
    KEGGiabc:ACICU_03580.
    PATRICi20715903. VBIAciBau103538_3600.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000863 Genomic DNA. Translation: ACC58889.1 .
    RefSeqi YP_001848236.1. NC_010611.1.

    3D structure databases

    ProteinModelPortali B2I1P1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405416.ACICU_03580.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC58889 ; ACC58889 ; ACICU_03580 .
    GeneIDi 6236047.
    KEGGi abc:ACICU_03580.
    PATRICi 20715903. VBIAciBau103538_3600.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284928.
    KOi K00763.
    OMAi QAVFHRY.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci ABAU405416:GI27-3654-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group."
      Iacono M., Villa L., Fortini D., Bordoni R., Imperi F., Bonnal R.J., Sicheritz-Ponten T., De Bellis G., Visca P., Cassone A., Carattoli A.
      Antimicrob. Agents Chemother. 52:2616-2625(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ACICU.

    Entry informationi

    Entry nameiPNCB_ACIBC
    AccessioniPrimary (citable) accession number: B2I1P1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3