B2I1J9 (PYRE_ACIBC) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 24.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Orotate phosphoribosyltransferase Short name=OPRT Short name=OPRTase EC=2.4.2.10 | ||||
| Gene names |
| ||||
| Organism | Acinetobacter baumannii (strain ACICU) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 405416 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex |
Protein attributes
| Sequence length | 216 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 |
| Catalytic activity | Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 |
| Cofactor | Magnesium By similarity. HAMAP MF_01208 |
| Pathway | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 |
| Subunit structure | Homodimer By similarity. HAMAP MF_01208 |
| Sequence similarities | Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pyrimidine biosynthesis |
| Ligand | Magnesium |
| Molecular function | Glycosyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | nucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | orotate phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 216 | 216 | Orotate phosphoribosyltransferase HAMAP MF_01208 | PRO_1000138755 | |||||
Regions | |||||||||
| Region | 38 – 39 | 2 | Orotate binding By similarity | ||||||
| Region | 75 – 76 | 2 | 5-phosphoribose 1-diphosphate binding By similarity | ||||||
| Region | 128 – 136 | 9 | 5-phosphoribose 1-diphosphate binding By similarity | ||||||
Sites | |||||||||
| Binding site | 30 | 1 | 5-phosphoribose 1-diphosphate By similarity | ||||||
| Binding site | 102 | 1 | 5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity | ||||||
| Binding site | 103 | 1 | 5-phosphoribose 1-diphosphate By similarity | ||||||
| Binding site | 106 | 1 | 5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity | ||||||
| Binding site | 108 | 1 | 5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity | ||||||
| Binding site | 132 | 1 | Orotate By similarity | ||||||
| Binding site | 160 | 1 | Orotate By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group." Iacono M., Villa L., Fortini D., Bordoni R., Imperi F., Bonnal R.J., Sicheritz-Ponten T., De Bellis G., Visca P., Cassone A., Carattoli A. Antimicrob. Agents Chemother. 52:2616-2625(2008) [PubMed: 18411315] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ACICU. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000863 Genomic DNA. Translation: ACC58847.1. |
| RefSeq | YP_001848194.1. NC_010611.1. |
3D structure databases | |
| ProteinModelPortal | B2I1J9. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | B2I1J9. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 6234671. |
| GenomeReviews | Gene locus ACICU_03538 in contig CP000863_GR. |
| KEGG | abc:ACICU_03538. |
| PATRIC | 20715819. VBIAciBau103538_3558. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG404341. |
| OMA | FAFNRKE. |
| ProtClustDB | PRK00455. |
Family and domain databases | |
| HAMAP | MF_01208. PyrE. [Tree] |
| InterPro | IPR004467. Or_phspho_trans_clade-1. IPR023031. Orotate_PribosylTferase. IPR000836. PRibTrfase. [Graphical view] |
| KO | K00762. |
| Pfam | PF00156. Pribosyltran. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00336. PyrE. 1 hit. |
| PROSITE | PS00103. PUR_PYR_PR_TRANSFER. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PYRE_ACIBC | ||||||||
| Accession | Primary (citable) accession number: B2I1J9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with