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B2I0K2 (MRAY_ACIBC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:ACICU_03398
OrganismAcinetobacter baumannii (strain ACICU) [Complete proteome] [HAMAP]
Taxonomic identifier405416 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000090580

Regions

Transmembrane25 – 4521Helical; Potential
Transmembrane73 – 9321Helical; Potential
Transmembrane98 – 11821Helical; Potential
Transmembrane134 – 15421Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane211 – 23121Helical; Potential
Transmembrane251 – 27121Helical; Potential
Transmembrane275 – 29521Helical; Potential
Transmembrane300 – 32021Helical; Potential
Transmembrane349 – 36921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B2I0K2 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 3CBE5DE5B81B67F0

FASTA37240,915
        10         20         30         40         50         60 
MLLWLFEQLA GYHSSFQVVR YLTLRSLLSV LTSLTIGLVL GPIMIRKLQA LKYGQAVSSF 

        70         80         90        100        110        120 
APENHAKKMG TPTMGGILIL LSIGISTLLW ADLSNPYVWI VLGVMVVFGA VGWADDWIKI 

       130        140        150        160        170        180 
RYKDNAGLPA RKKFFWTSVA SLGAGIALYL IATQQSNAEY TANMLDLLIP FFKNLSIPLS 

       190        200        210        220        230        240 
IVPLGLAFIV FTYLVINGAS NAVNLTDGLD GLAIMPVVMV ATGLGVFAYL SGDIRFANYL 

       250        260        270        280        290        300 
HIPYVKYTSE LVVICSAMIG AGLAFLWYNA HPAQVFMGDV GALALGAMLG TIAVMVRQEI 

       310        320        330        340        350        360 
VFAIMGGVFV MEAVSVFLQI GSLRMRNKRV FLMAPLHHHY EKQGWKETQV VIRFWIITIM 

       370 
LVVLGLMTLK LR

« Hide

References

[1]"Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group."
Iacono M., Villa L., Fortini D., Bordoni R., Imperi F., Bonnal R.J., Sicheritz-Ponten T., De Bellis G., Visca P., Cassone A., Carattoli A.
Antimicrob. Agents Chemother. 52:2616-2625(2008) [PubMed: 18411315] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ACICU.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000863 Genomic DNA. Translation: ACC58708.1.
RefSeqYP_001848055.1. NC_010611.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB2I0K2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6234974.
GenomeReviewsGene locus ACICU_03398 in contig CP000863_GR.
KEGGabc:ACICU_03398.
PATRIC20715535. VBIAciBau103538_3424.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG708263.
OMAAGGLMFY.
ProtClustDBPRK00108.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_ACIBC
AccessionPrimary (citable) accession number: B2I0K2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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