Reviewed, UniProtKB/Swiss-Prot B2I0J2 (AROB_ACIBC)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	ACICU_03388

Organism

Acinetobacter baumannii (strain ACICU) [Complete proteome] [HAMAP]

Taxonomic identifier

405416 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. HAMAP MF_00110 NAD By similarity. HAMAP MF_00110
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity. HAMAP MF_00110
Subcellular location	Cytoplasm By similarity HAMAP MF_00110.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 360	360	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000094438

Sequences

	Sequence		Length	Mass (Da)
	B2I0J2-1 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 2849EEA2CECDBE3D	FASTA	360	39,522
	10 20 30 40 50 60 MQTLHVELGE RRYPIFIGSQ LDPEQLLEPY IHGQQVMIVS NVTVAPLYLS HYQEALESLG 70 80 90 100 110 120 KTVATCILPD GEKYKDIQHL NLIFDALLEV GFNRDCTVLA LGGGVIGDMA GFASACFQRG 130 140 150 160 170 180 VYFVQVPTTL LSQVDSSVGG KTGINHPLGK NMLGAFQQPQ VVLADMAQLN TLPERELSAG 190 200 210 220 230 240 LAEVIKYALL GDEDFLVWLE ENMDGLVARD ADLLAEAVYR SCAHKARIVA NDEKEQGERA 250 260 270 280 290 300 LLNLGHTFGH AIESYLGYGT WLHGEAVATG MVMAADLSQR LGWISNEDVA RTKKIIQRAN 310 320 330 340 350 360 LPISCPQIPL DDFLGYMAHD KKVLNGQLRL VLLKQLGQAV ITKDFDVELM KQAILANQHG

References

[1]

"Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group." Iacono M., Villa L., Fortini D., Bordoni R., Imperi F., Bonnal R.J., Sicheritz-Ponten T., De Bellis G., Visca P., Cassone A., Carattoli A. Antimicrob. Agents Chemother. 52:2616-2625(2008) [PubMed: 18411315] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000863 Genomic DNA. Translation: ACC58698.1.
RefSeq	YP_001848045.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6237235.
GenomeReviews	Gene locus ACICU_03388 in contig CP000863_GR.
KEGG	abc:ACICU_03388.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG632303.
OMA	APESMDF.
Family and domain databases
HAMAP	MF_00110. DHQ_synthase. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_ACIBC

Accession

Primary (citable) accession number: B2I0J2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	June 10, 2008
Last modified:	February 9, 2010
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)