B2I0B7 (AROC_ACIBC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	ACICU_01730

Organism

Acinetobacter baumannii (strain ACICU) [Complete proteome] [HAMAP]

Taxonomic identifier

405416 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	Chorismate synthase HAMAP MF_00300		PRO_1000115318

Sequences

	Sequence		Length	Mass (Da)
	B2I0B7 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: C070FB20F535E468	FASTA	363	38,987
	10 20 30 40 50 60 MAGNSIGQLF RVTTCGESHG VGLMAIVDGV PPGLALTEED LQKDLDRRKP GTSKFATQRK 70 80 90 100 110 120 EPDQVEIISG VFEGKTTGTP IGLLIRNTDQ KSKDYGNIAQ TFRPGHADYT YTQKYGFRDY 130 140 150 160 170 180 RGGGRSSARE TAMRVAAGAI AKKYLAEKFG VVIRGHVTQI GNEVAEKLDW NEVPNNPFFC 190 200 210 220 230 240 GDVDAVPRFE ALVTSLREQG TSCGAKLEIL AEKVPVGWGE PVFDRLDADI AHAMMSINAV 250 260 270 280 290 300 KGVEIGDGFA VAGQFGHETR DELTSHGFLA NHAGGILGGI SSGQTIRVAI ALKPTASITT 310 320 330 340 350 360 PGKTINLNRE DTDVLTKGRH DPCVGVRATP IAEAMLAIVL MDHFLRHRAQ NADVVPPFAP IEP

References

[1]

"Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group." Iacono M., Villa L., Fortini D., Bordoni R., Imperi F., Bonnal R.J., Sicheritz-Ponten T., De Bellis G., Visca P., Cassone A., Carattoli A. Antimicrob. Agents Chemother. 52:2616-2625(2008) [PubMed: 18411315] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ACICU.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000863 Genomic DNA. Translation: ACC57042.1.
RefSeq	YP_001846389.1. NC_010611.1.
3D structure databases
ProteinModelPortal	B2I0B7.
ModBase	Search...
Protein-protein interaction databases
STRING	B2I0B7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6236505.
GenomeReviews	Gene locus ACICU_01730 in contig CP000863_GR.
KEGG	abc:ACICU_01730.
PATRIC	20712226. VBIAciBau103538_1803.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG292336.
OMA	SRFTTQR.
ProtClustDB	PRK05382.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_ACIBC

Accession

Primary (citable) accession number: B2I0B7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	June 10, 2008
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program