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Reviewed, UniProtKB/Swiss-Prot B2HWW3 (SERC_ACIBC)

Last modified November 3, 2009. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Phosphoserine aminotransferase
    EC=2.6.1.52
Alternative name(s):
    Phosphohydroxythreonine aminotransferase
      Short name=PSAT
Gene names
Name: serC
Ordered Locus Names: ACICU_02860
OrganismAcinetobacter baumannii (strain ACICU) [Complete proteome] [HAMAP]
Taxonomic identifier405416 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

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Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine By similarity.

Catalytic activity

O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate. HAMAP MF_00160

4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate. HAMAP MF_00160

Cofactor

Binds 1 pyridoxal phosphate per subunit By similarity.

Pathway

Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3. HAMAP MF_00160

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5. HAMAP MF_00160

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Phosphoserine aminotransferase HAMAP MF_00160
PRO_1000097200

Regions

Region75 – 762Pyridoxal phosphate binding By similarity
Region236 – 2372Pyridoxal phosphate binding By similarity

Sites

Binding site411L-glutamate By similarity
Binding site1011Pyridoxal phosphate By similarity
Binding site1521Pyridoxal phosphate By similarity
Binding site1711Pyridoxal phosphate By similarity
Binding site1941Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue1951N6-(pyridoxal phosphate)lysine By similarity

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Sequences

Sequence LengthMass (Da)Tools
B2HWW3-1 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 3ED422F19885E346

FASTA35939,339
        10         20         30         40         50         60 
MRAYNFCAGP AALPTAVLEK AQQELLDWQG KGLSIMEMSH RSADYVAVAE KAEADLRKLM 

        70         80         90        100        110        120 
NIPENYKVLF LQGGASLQFS AIPLNLLGKN NKADYIHTGI WSEKALKEAK RYGDINVVEA 

       130        140        150        160        170        180 
GIKVDGKFAI SEQSEWNLSD DAAYVHYADN ETIGGLQFAG VPDVKAPLVC DFSSSILSAP 

       190        200        210        220        230        240 
LDVSKFGLIY AGAQKNIGPA GLTIVIIRDD LLDQAKAEIP SILKYADQAK NGSMVNTPST 

       250        260        270        280        290        300 
YAWYLSGLVF EWLLEQGGVD AIHKVNLEKA QLLYGYIDSS DFYNNPIAIP NRSIMNVPFT 

       310        320        330        340        350 
LADEALEKQF LKEAEENHLL NLAGHRSVGG MRASIYNAVP LEGVQALIRF MDDFAKRNG

« Hide

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References

[1]"Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group."
Iacono M., Villa L., Fortini D., Bordoni R., Imperi F., Bonnal R.J., Sicheritz-Ponten T., De Bellis G., Visca P., Cassone A., Carattoli A.
Antimicrob. Agents Chemother. 52:2616-2625(2008) [PubMed: 18411315] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000863 Genomic DNA. Translation: ACC58172.1.
RefSeqYP_001847519.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID6234402.
GenomeReviewsGene locus ACICU_02860 in contig CP000863_GR.
KEGGabc:ACICU_02860.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMASMYNTPP.

Family and domain databases

HAMAPMF_00160.
[Tree]
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR003248. Pser_amintransf.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
TIGRFAMsTIGR01364. serC_1. 1 hit.
PROSITEPS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameSERC_ACIBC
AccessionPrimary (citable) accession number: B2HWW3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: November 3, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents