B2HWU2 (F16PA_ACIBC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fructose-1,6-bisphosphatase class 1
Short name=FBPase class 1
EC=3.1.3.11

Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Gene names

Name:	fbp
Ordered Locus Names:	ACICU_02839

Organism

Acinetobacter baumannii (strain ACICU) [Complete proteome] [HAMAP]

Taxonomic identifier

405416 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855
Cofactor	Binds 2 magnesium ions per subunit By similarity. HAMAP MF_01855
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855
Subunit structure	Homotetramer By similarity. HAMAP MF_01855
Subcellular location	Cytoplasm Potential HAMAP MF_01855.
Sequence similarities	Belongs to the FBPase class 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	fructose 1,6-bisphosphate 1-phosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Fructose-1,6-bisphosphatase class 1 HAMAP MF_01855		PRO_0000364447
Regions
	Region	110 – 113	4	Substrate binding By similarity
Sites
	Metal binding	88	1	Magnesium 1 By similarity
	Metal binding	107	1	Magnesium 1 By similarity
	Metal binding	107	1	Magnesium 2 By similarity
	Metal binding	109	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	110	1	Magnesium 2 By similarity
	Metal binding	272	1	Magnesium 2 By similarity
	Binding site	200	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2HWU2 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 0A0E821E53C51F94	FASTA	323	35,456
	10 20 30 40 50 60 MSNLTLSQFL QQEKGNLTPE LAQVIDTIAA TCKTIDQALQ KGALAGILGS AGNENVQGET 70 80 90 100 110 120 QKKLDVISND YLIDALKVHP HVGGLASEEL DDFTPAQENG EYLVLFDPLD GSSNIDINMC 130 140 150 160 170 180 VGTIFSILPA KNAVTQAQDF MQAGTQQVAA GYVLYGPSTM MALTVGNGVA FFTLDPETQT 190 200 210 220 230 240 FLLTTENVQV SADTQEFAIN ASNQRHWEQP VKQYIEELLA GKTSVREKDF NMRWVACMVG 250 260 270 280 290 300 DVHRILCRGG IFLYPYDLKD PKKAGRLRLM YEANPMSMLI EQAGGASTTG RVRILEIEPT 310 320 ELHQRVPVII GSKNEVERVT SYH

References

[1]

"Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group." Iacono M., Villa L., Fortini D., Bordoni R., Imperi F., Bonnal R.J., Sicheritz-Ponten T., De Bellis G., Visca P., Cassone A., Carattoli A. Antimicrob. Agents Chemother. 52:2616-2625(2008) [PubMed: 18411315] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ACICU.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000863 Genomic DNA. Translation: ACC58151.1.
RefSeq	YP_001847498.1. NC_010611.1.
3D structure databases
ProteinModelPortal	B2HWU2.
ModBase	Search...
Protein-protein interaction databases
STRING	B2HWU2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6234643.
GenomeReviews	Gene locus ACICU_02839 in contig CP000863_GR.
KEGG	abc:ACICU_02839.
PATRIC	20714388. VBIAciBau103538_2872.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG731261.
OMA	HWEAPVQ.
ProtClustDB	PRK09293.
Family and domain databases
HAMAP	MF_01855. FBPase_class1. [Tree]
InterPro	IPR000146. FBPase_class-1/SBPase. [Graphical view]
KO	K03841.
PANTHER	PTHR11556. In_FB_phphtase. 1 hit.
Pfam	PF00316. FBPase. 1 hit. [Graphical view]
PIRSF	PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTS	PR00115. F16BPHPHTASE.
PROSITE	PS00124. FBPASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F16PA_ACIBC

Accession

Primary (citable) accession number: B2HWU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	June 10, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program