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Protein

Fructose-1,6-bisphosphatase class 1

Gene

fbp

Organism
Acinetobacter baumannii (strain ACICU)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi88 – 881Magnesium 1UniRule annotation
Metal bindingi107 – 1071Magnesium 1UniRule annotation
Metal bindingi107 – 1071Magnesium 2UniRule annotation
Metal bindingi109 – 1091Magnesium 1; via carbonyl oxygenUniRule annotation
Metal bindingi110 – 1101Magnesium 2UniRule annotation
Binding sitei200 – 2001SubstrateUniRule annotation
Metal bindingi272 – 2721Magnesium 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciABAU405416:GI27-2887-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-1,6-bisphosphatase class 1UniRule annotation (EC:3.1.3.11UniRule annotation)
Short name:
FBPase class 1UniRule annotation
Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1UniRule annotation
Gene namesi
Name:fbpUniRule annotation
Ordered Locus Names:ACICU_02839
OrganismiAcinetobacter baumannii (strain ACICU)
Taxonomic identifieri405416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Fructose-1,6-bisphosphatase class 1PRO_0000364447Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB2HWU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 1134Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the FBPase class 1 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000191264.
KOiK03841.
OMAiYTTRYIG.
OrthoDBiEOG6X10TR.

Family and domain databases

HAMAPiMF_01855. FBPase_class1.
InterProiIPR000146. FBPase_class-1.
IPR033391. FBPase_N.
IPR028343. FBPtase.
[Graphical view]
PANTHERiPTHR11556. PTHR11556. 1 hit.
PfamiPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFiPIRSF500210. FBPtase. 1 hit.
PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSiPR00115. F16BPHPHTASE.

Sequencei

Sequence statusi: Complete.

B2HWU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNLTLSQFL QQEKGNLTPE LAQVIDTIAA TCKTIDQALQ KGALAGILGS
60 70 80 90 100
AGNENVQGET QKKLDVISND YLIDALKVHP HVGGLASEEL DDFTPAQENG
110 120 130 140 150
EYLVLFDPLD GSSNIDINMC VGTIFSILPA KNAVTQAQDF MQAGTQQVAA
160 170 180 190 200
GYVLYGPSTM MALTVGNGVA FFTLDPETQT FLLTTENVQV SADTQEFAIN
210 220 230 240 250
ASNQRHWEQP VKQYIEELLA GKTSVREKDF NMRWVACMVG DVHRILCRGG
260 270 280 290 300
IFLYPYDLKD PKKAGRLRLM YEANPMSMLI EQAGGASTTG RVRILEIEPT
310 320
ELHQRVPVII GSKNEVERVT SYH
Length:323
Mass (Da):35,456
Last modified:June 10, 2008 - v1
Checksum:i0A0E821E53C51F94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000863 Genomic DNA. Translation: ACC58151.1.
RefSeqiWP_000067971.1. NC_010611.1.

Genome annotation databases

EnsemblBacteriaiACC58151; ACC58151; ACICU_02839.
KEGGiabc:ACICU_02839.
PATRICi20714388. VBIAciBau103538_2872.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000863 Genomic DNA. Translation: ACC58151.1.
RefSeqiWP_000067971.1. NC_010611.1.

3D structure databases

ProteinModelPortaliB2HWU2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACC58151; ACC58151; ACICU_02839.
KEGGiabc:ACICU_02839.
PATRICi20714388. VBIAciBau103538_2872.

Phylogenomic databases

HOGENOMiHOG000191264.
KOiK03841.
OMAiYTTRYIG.
OrthoDBiEOG6X10TR.

Enzyme and pathway databases

UniPathwayiUPA00138.
BioCyciABAU405416:GI27-2887-MONOMER.

Family and domain databases

HAMAPiMF_01855. FBPase_class1.
InterProiIPR000146. FBPase_class-1.
IPR033391. FBPase_N.
IPR028343. FBPtase.
[Graphical view]
PANTHERiPTHR11556. PTHR11556. 1 hit.
PfamiPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFiPIRSF500210. FBPtase. 1 hit.
PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSiPR00115. F16BPHPHTASE.
ProtoNetiSearch...

Publicationsi

  1. "Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group."
    Iacono M., Villa L., Fortini D., Bordoni R., Imperi F., Bonnal R.J., Sicheritz-Ponten T., De Bellis G., Visca P., Cassone A., Carattoli A.
    Antimicrob. Agents Chemother. 52:2616-2625(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ACICU.

Entry informationi

Entry nameiF16PA_ACIBC
AccessioniPrimary (citable) accession number: B2HWU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 10, 2008
Last modified: May 11, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.