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Protein

Uroporphyrinogen decarboxylase

Gene

hemE

Organism
Acinetobacter baumannii (strain ACICU)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.UniRule annotation

Catalytic activityi

Uroporphyrinogen III = coproporphyrinogen + 4 CO2.UniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Uroporphyrinogen decarboxylase (hemE)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Sitei77 – 771Transition state stabilizerUniRule annotation
Binding sitei154 – 1541SubstrateUniRule annotation
Binding sitei209 – 2091SubstrateUniRule annotation
Binding sitei330 – 3301SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciABAU405416:GI27-2614-MONOMER.
UniPathwayiUPA00251; UER00321.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen decarboxylaseUniRule annotation (EC:4.1.1.37UniRule annotation)
Short name:
UPDUniRule annotation
Short name:
URO-DUniRule annotation
Gene namesi
Name:hemEUniRule annotation
Ordered Locus Names:ACICU_02568
OrganismiAcinetobacter baumannii (strain ACICU)
Taxonomic identifieri405416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Uroporphyrinogen decarboxylasePRO_1000099966Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni27 – 315Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the uroporphyrinogen decarboxylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000253897.
KOiK01599.
OMAiGSSKDFR.

Family and domain databases

CDDicd00717. URO-D. 1 hit.
HAMAPiMF_00218. URO_D. 1 hit.
InterProiIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PfamiPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01464. hemE. 1 hit.
PROSITEiPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2HVF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTLKNDRFL RALLREPVDT TPIWMMRQAG RYLPEYRETR SKAGDFLSLC
60 70 80 90 100
KNTEFACEVT LQPLRRYDLD AAILFSDILT IPDALGLGLY FETGEGPKFH
110 120 130 140 150
KTVRTEQDVA NLPKLNAKAD LDYVMNAVST IRSALGGQVP LIGFSGSPWT
160 170 180 190 200
LATYMVEGGS SKEFRFTKQM MYAQPEVLHA LLDHLADSVI DYLNAQIDAG
210 220 230 240 250
AQAIQIFDSW GGALAHREYV EFSLNYMNKI IAGLQREKDG RRIPVIVFTK
260 270 280 290 300
GGGQWLEPMI ASGADALGLD WTTPLNTARN VVSGRVALQG NLDPAVLYGS
310 320 330 340 350
AASIEKAVKA MLDDAYANGE KTGYVANLGH GITQWVDPAQ PKIFVDTVHE

YSAKYLG
Length:357
Mass (Da):39,378
Last modified:June 10, 2008 - v1
Checksum:i57D816D1A71A5C6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000863 Genomic DNA. Translation: ACC57880.1.
RefSeqiWP_000209403.1. NC_010611.1.

Genome annotation databases

EnsemblBacteriaiACC57880; ACC57880; ACICU_02568.
KEGGiabc:ACICU_02568.
PATRICi20713872. VBIAciBau103538_2617.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000863 Genomic DNA. Translation: ACC57880.1.
RefSeqiWP_000209403.1. NC_010611.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACC57880; ACC57880; ACICU_02568.
KEGGiabc:ACICU_02568.
PATRICi20713872. VBIAciBau103538_2617.

Phylogenomic databases

HOGENOMiHOG000253897.
KOiK01599.
OMAiGSSKDFR.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00321.
BioCyciABAU405416:GI27-2614-MONOMER.

Family and domain databases

CDDicd00717. URO-D. 1 hit.
HAMAPiMF_00218. URO_D. 1 hit.
InterProiIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PfamiPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01464. hemE. 1 hit.
PROSITEiPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCUP_ACIBC
AccessioniPrimary (citable) accession number: B2HVF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: September 7, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.