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B2HV79

- BETA_ACIBC

UniProt

B2HV79 - BETA_ACIBC

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Protein
Oxygen-dependent choline dehydrogenase
Gene
betA, ACICU_00888
Organism
Acinetobacter baumannii (strain ACICU)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei477 – 4771 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 3630FAD By similarity
Add
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciABAU405416:GI27-921-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:ACICU_00888
OrganismiAcinetobacter baumannii (strain ACICU)
Taxonomic identifieri405416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
ProteomesiUP000008839: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 552552Oxygen-dependent choline dehydrogenaseUniRule annotation
PRO_1000133317Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi405416.ACICU_00888.

Structurei

3D structure databases

ProteinModelPortaliB2HV79.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2HV79-1 [UniParc]FASTAAdd to Basket

« Hide

MNIKEYDYII IGAGSAGNVL AARLTEDKDT TVLLLEAGGP DYRLDFRTQM    50
PAALAYPLQG RRYNWAYLTD PEPHMNNRRM ECGRGKGLGG SSLINGMCYI 100
RGNAMDLEQW ATHKGLENWT YADCLPYYKK AETRDIGGND YHGDSGPVSV 150
ATPKNGNNVL FHAMVEAGVQ AGYPRTDDLN GYQQEGFGPM DRTVTPKGRR 200
SSTARGYLDM AKGRPNLTIL THATTNKILF NQKQAIGVEY IIGADQNNLQ 250
RALVKREVLL CAGAIASPQI LQRSGVGQST FLKSMDIDVV HDLPGVGENL 300
QDHLEMYLQY KCKQPVSLYP ALKWYNQPAI GAEWLFNGTG IGASNQFEAG 350
GFIRSSDEFK WPNIQYHFLP VAINYNGSNA VKEHGFQAHV GSMRSPSRGR 400
IKLKSKDPFA HPSILFNYMS TEQDWREFRD AIRITREIMH QPALDPYRGD 450
EISPGKHLQT DAELDDFVRN HAETAYHPSC SCKMGEDEMA VVDGQGRVHG 500
MNGLRVVDAS IMPLIITGNL NATTIMIAEK IADQIRGREA LPRSTAPFYV 550
AS 552
Length:552
Mass (Da):61,302
Last modified:June 10, 2008 - v1
Checksum:iB1B3FF7E0172F7FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000863 Genomic DNA. Translation: ACC56200.1.
RefSeqiYP_001845547.1. NC_010611.1.

Genome annotation databases

EnsemblBacteriaiACC56200; ACC56200; ACICU_00888.
GeneIDi6236646.
KEGGiabc:ACICU_00888.
PATRICi20710569. VBIAciBau103538_0982.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000863 Genomic DNA. Translation: ACC56200.1 .
RefSeqi YP_001845547.1. NC_010611.1.

3D structure databases

ProteinModelPortali B2HV79.
ModBasei Search...

Protein-protein interaction databases

STRINGi 405416.ACICU_00888.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC56200 ; ACC56200 ; ACICU_00888 .
GeneIDi 6236646.
KEGGi abc:ACICU_00888.
PATRICi 20710569. VBIAciBau103538_0982.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci ABAU405416:GI27-921-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group."
    Iacono M., Villa L., Fortini D., Bordoni R., Imperi F., Bonnal R.J., Sicheritz-Ponten T., De Bellis G., Visca P., Cassone A., Carattoli A.
    Antimicrob. Agents Chemother. 52:2616-2625(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ACICU.

Entry informationi

Entry nameiBETA_ACIBC
AccessioniPrimary (citable) accession number: B2HV79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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