B2HV79 (BETA_ACIBC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Choline dehydrogenase
Short name=CDH
Short name=CHD
EC=1.1.99.1

Gene names

Name:	betA
Ordered Locus Names:	ACICU_00888

Organism

Acinetobacter baumannii (strain ACICU) [Complete proteome] [HAMAP]

Taxonomic identifier

405416 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length	552 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750
Cofactor	FAD By similarity. HAMAP MF_00750
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: InterPro
Molecular function	choline dehydrogenase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 552	552	Choline dehydrogenase HAMAP MF_00750		PRO_1000133317
Regions
	Nucleotide binding	7 – 36	30	FAD Potential
Sites
	Active site	477	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2HV79 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: B1B3FF7E0172F7FD	FASTA	552	61,302
	10 20 30 40 50 60 MNIKEYDYII IGAGSAGNVL AARLTEDKDT TVLLLEAGGP DYRLDFRTQM PAALAYPLQG 70 80 90 100 110 120 RRYNWAYLTD PEPHMNNRRM ECGRGKGLGG SSLINGMCYI RGNAMDLEQW ATHKGLENWT 130 140 150 160 170 180 YADCLPYYKK AETRDIGGND YHGDSGPVSV ATPKNGNNVL FHAMVEAGVQ AGYPRTDDLN 190 200 210 220 230 240 GYQQEGFGPM DRTVTPKGRR SSTARGYLDM AKGRPNLTIL THATTNKILF NQKQAIGVEY 250 260 270 280 290 300 IIGADQNNLQ RALVKREVLL CAGAIASPQI LQRSGVGQST FLKSMDIDVV HDLPGVGENL 310 320 330 340 350 360 QDHLEMYLQY KCKQPVSLYP ALKWYNQPAI GAEWLFNGTG IGASNQFEAG GFIRSSDEFK 370 380 390 400 410 420 WPNIQYHFLP VAINYNGSNA VKEHGFQAHV GSMRSPSRGR IKLKSKDPFA HPSILFNYMS 430 440 450 460 470 480 TEQDWREFRD AIRITREIMH QPALDPYRGD EISPGKHLQT DAELDDFVRN HAETAYHPSC 490 500 510 520 530 540 SCKMGEDEMA VVDGQGRVHG MNGLRVVDAS IMPLIITGNL NATTIMIAEK IADQIRGREA 550 LPRSTAPFYV AS

References

[1]

"Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group." Iacono M., Villa L., Fortini D., Bordoni R., Imperi F., Bonnal R.J., Sicheritz-Ponten T., De Bellis G., Visca P., Cassone A., Carattoli A. Antimicrob. Agents Chemother. 52:2616-2625(2008) [PubMed: 18411315] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ACICU.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000863 Genomic DNA. Translation: ACC56200.1.
RefSeq	YP_001845547.1. NC_010611.1.
3D structure databases
ProteinModelPortal	B2HV79.
ModBase	Search...
Protein-protein interaction databases
STRING	B2HV79.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6236646.
GenomeReviews	Gene locus ACICU_00888 in contig CP000863_GR.
KEGG	abc:ACICU_00888.
PATRIC	20710569. VBIAciBau103538_0982.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG734713.
OMA	EISPGAH.
ProtClustDB	PRK02106.
Family and domain databases
HAMAP	MF_00750. Choline_dehydrogen. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
KO	K00108.
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. BetA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETA_ACIBC

Accession

Primary (citable) accession number: B2HV79

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	June 10, 2008
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program