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B2HUA6

- B2HUA6_ACIBC

UniProt

B2HUA6 - B2HUA6_ACIBC

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Protein

Alanine racemase

Gene
ACICU_02378
Organism
Acinetobacter baumannii (strain ACICU)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Active sitei254 – 2541Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei302 – 3021Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciABAU405416:GI27-2416-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:ACICU_02378Imported
OrganismiAcinetobacter baumannii (strain ACICU)Imported
Taxonomic identifieri405416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
ProteomesiUP000008839: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi405416.ACICU_02378.

Structurei

3D structure databases

ProteinModelPortaliB2HUA6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031446.
KOiK01775.
OMAiPSECAGV.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

B2HUA6-1 [UniParc]FASTAAdd to Basket

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MRQATVYIDR QALQYNLNRV KQLAANSKIV SMVKANAYGH GVKDCLAALN    50
ASDAFGVACL QEGLEIRELG FEQPVTLIEG VFSEDEMPVA IEQKFECVIH 100
HQQQFEWLIK HKQAYIAQGL KVWVKLNSGM NRLGFKDPEI IEVIKTLKSE 150
GFTCVLAMHF ANADVDHPLN EQQKQQFLHI KETCDPILAS CCNSAAIFKW 200
PELNFDYVRP GIMLYGASPF ADKTVHDLDL KPVMTFTAEI IALNHIEAGE 250
HVGYGSTFCA QQAMDIAIVS IGYGDGYPRA YVKQNFVAID GKLCPVVGRV 300
SMDMIAIDVT NTQVKLGTQV ELWGNHRLVD DVAEANGTIG YELLCRLSSR 350
PVRQGT 356
Length:356
Mass (Da):39,596
Last modified:June 10, 2008 - v1
Checksum:iC22130CED5FD32AE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000863 Genomic DNA. Translation: ACC57690.1.
RefSeqiYP_001847037.1. NC_010611.1.

Genome annotation databases

EnsemblBacteriaiACC57690; ACC57690; ACICU_02378.
GeneIDi6235256.
KEGGiabc:ACICU_02378.
PATRICi20713481. VBIAciBau103538_2430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000863 Genomic DNA. Translation: ACC57690.1 .
RefSeqi YP_001847037.1. NC_010611.1.

3D structure databases

ProteinModelPortali B2HUA6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405416.ACICU_02378.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC57690 ; ACC57690 ; ACICU_02378 .
GeneIDi 6235256.
KEGGi abc:ACICU_02378.
PATRICi 20713481. VBIAciBau103538_2430.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031446.
KOi K01775.
OMAi PSECAGV.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci ABAU405416:GI27-2416-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group."
    Iacono M., Villa L., Fortini D., Bordoni R., Imperi F., Bonnal R.J., Sicheritz-Ponten T., De Bellis G., Visca P., Cassone A., Carattoli A.
    Antimicrob. Agents Chemother. 52:2616-2625(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ACICUImported.

Entry informationi

Entry nameiB2HUA6_ACIBC
AccessioniPrimary (citable) accession number: B2HUA6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: July 9, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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