Reviewed, UniProtKB/Swiss-Prot B2HTC8 (ILVC_ACIBC)

Names and origin

Protein names

Recommended name:
    Ketol-acid reductoisomerase
    EC=1.1.1.86
Alternative name(s):
    Acetohydroxy-acid isomeroreductase
    Alpha-keto-beta-hydroxylacil reductoisomerase

Gene names

Name:	ilvC
Ordered Locus Names:	ACICU_00553

Organism

Acinetobacter baumannii (strain ACICU) [Complete proteome] [HAMAP]

Taxonomic identifier

405416 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435 (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435
Sequence similarities	Belongs to the ketol-acid reductoisomerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoleucine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW valine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	binding Inferred from electronic annotation. Source: InterPro ketol-acid reductoisomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Ketol-acid reductoisomerase HAMAP MF_00435		PRO_1000124242
Sites
	Active site	107	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	B2HTC8-1 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 69B4BA729A6888DE	FASTA	338	36,853
	10 20 30 40 50 60 MQIFYDKDCD LSIIQSKKVA IIGYGSQGHA HALNLKDSGV DVTVGLRAGS ASWKKAENAG 70 80 90 100 110 120 LKVAEVPAAV KQADLVMILT PDEFQSQLYR DVIEPNIKEG ATLAFAHGFS VLYNQVVPRK 130 140 150 160 170 180 DLDVIMVAPK APGHTVRSEF QRGSGVPDLI AIHQDASGNA RNVALSYASG VGGGRTGIIE 190 200 210 220 230 240 TSFREETETD LFGEQAVLCG GAVELVKMGF ETLVEAGYAP EMAYFECLHE LKLIVDLMFE 250 260 270 280 290 300 GGIADMNYSV SNNAEYGEYV TGPEVINEQS REAMRNALKR IQSGEYAKMF IQEGALNYPS 310 320 330 MTARRRQNAA HGIEQTGAKL RAMMPWIQAN KIVDKEKN

References

[1]

"Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group." Iacono M., Villa L., Fortini D., Bordoni R., Imperi F., Bonnal R.J., Sicheritz-Ponten T., De Bellis G., Visca P., Cassone A., Carattoli A. Antimicrob. Agents Chemother. 52:2616-2625(2008) [PubMed: 18411315] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000863 Genomic DNA. Translation: ACC55865.1.
RefSeq	YP_001845212.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6236845.
GenomeReviews	Gene locus ACICU_00553 in contig CP000863_GR.
KEGG	abc:ACICU_00553.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	AHGFNIR.
Family and domain databases
HAMAP	MF_00435. [Tree]
InterPro	IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013116. IlvN. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR21371. AcH_isomrdctse. 1 hit.
Pfam	PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view]
TIGRFAMs	TIGR00465. ilvC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ILVC_ACIBC

Accession

Primary (citable) accession number: B2HTC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	June 10, 2008
Last modified:	November 3, 2009
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)