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B2HT41 (B2HT41_MYCMM) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2 HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH EMBL ACC42762.1
Synonyms:ispH2 HAMAP MF_00191
Ordered Locus Names:MMAR_4355
OrganismMycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]
Taxonomic identifier216594 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191 SAAS SAAS003451

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191 SAAS SAAS003451

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191 SAAS SAAS003451

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
B2HT41 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 0FB24C604FD034AE

FASTA33235,985
        10         20         30         40         50         60 
MVPTIDMGIP GASSSVAHVP TRRRVLLAEP RGYCAGVDRA VETVERALEK HGPPVYVRHE 

        70         80         90        100        110        120 
IVHNRHVVDT LAKAGAVFVE ETDQVPEGAI VVFSAHGVAP TVYAAAAERN LQTIDATCPL 

       130        140        150        160        170        180 
VTKVHNEARR FARNDYDILL IGHEGHEEVV GTAGEAPEHV QLVDGLDGAE RVTIRDEEKV 

       190        200        210        220        230        240 
VWLSQTTLSV DETMEIVARL RQRFPKLQDP PSDDICYATQ NRQVAVKAMA PECDLVLVVG 

       250        260        270        280        290        300 
SRNSSNSVRL VEVALGAGAQ AAYLVDWADD IDQSWLQGVT TVGVTSGASV PEVLVRGVLE 

       310        320        330 
RLAESGYDMV QPVTTANETL VFALPREIRP AR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000854 Genomic DNA. Translation: ACC42762.1.
RefSeqYP_001852617.1. NC_010612.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB2HT41.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000031805; EBMYCP00000030245; EBMYCG00000031800.
GeneID6228637.
GenomeReviewsGene locus MMAR_4355 in contig CP000854_GR.
KEGGmmi:MMAR_4355.
PATRIC18070031. VBIMycMar75906_4681.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016858.
HOGENOMHBG335228.
OMAAMAPECD.
ProtClustDBPRK01045.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB2HT41_MYCMM
AccessionPrimary (citable) accession number: B2HT41
Entry history
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: December 14, 2011
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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