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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciMMAR216594:GJOB-998-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:MMAR_0995
OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
Taxonomic identifieri216594 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000001190 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11761176DNA-directed RNA polymerase subunit betaPRO_1000141714Add
BLAST

Proteomic databases

PRIDEiB2HSJ3.

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Protein-protein interaction databases

STRINGi216594.MMAR_0995.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IIJ. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiEOG6M9DS6.

Family and domain databases

Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
HAMAPiMF_01321. RNApol_bact_RpoB.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 3 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2HSJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEGRILADF RQTDASLHQG RPQSSSNSSV PGAPNRVSFA KLREPLEVPG
60 70 80 90 100
LLDVQTDSFE WLIGSQRWRE SAAQRGDATP VGGLEEVLYE LSPIEDFSGS
110 120 130 140 150
MSLSFSDPRF DEVKAPVDEC KDKDMTYAAP LFVTAEFINN NTGEIKSQTV
160 170 180 190 200
FMGDFPMMTE KGTFIINGTE RVVVSQLVRS PGVYFDETID KSTDKLLHSV
210 220 230 240 250
KVIPSRGAWL EFDVDKRDTV GVRIDRKRRQ PVTVLLKALG WSNEQIHERF
260 270 280 290 300
GFSEIMMGTL EKDNTAGTDE ALLDIYRKLR PGEPPTKESA QTLLENLFFK
310 320 330 340 350
EKRYDLARVG RYKVNKKLGL NAGQPITSST LTEEDVVATI EYLVRLHEGQ
360 370 380 390 400
TAMTAPGGVE VPVETDDIDH FGNRRLRTVG ELIQNQIRVG MSRMERVVRE
410 420 430 440 450
RMTTQDVEAI TPQTLINIRP VVAAIKEFFG TSQLSQFMDQ NNPLSGLTHK
460 470 480 490 500
RRLSALGPGG LSRERAGLEV RDVHPSHYGR MCPIETPEGP NIGLIGSLSV
510 520 530 540 550
YARVNPFGFI ETPYRKVVDG VVSDEIHYLT ADEEDRHVVA QANSPIDAQG
560 570 580 590 600
RFVEPRVLVR RKAGEVEYVP SSEVDYMDVS PRQMVSVATA MIPFLEHDDA
610 620 630 640 650
NRALMGANMQ RQAVPLVRSE APLVGTGMEL RAAIDAGDVV VADKAGVIEE
660 670 680 690 700
VSADYITVMA DDGTRHTYRM RKFARSNHGT CANQSPIVDA GERVEAGQVI
710 720 730 740 750
ADGPCTQNGE MALGKNLLVA IMPWEGHNYE DAIILSNRLV EEDVLTSIHI
760 770 780 790 800
EEHEIDARDT KLGAEEITRD IPNVSDEVLA DLDERGIVRI GAEVRDGDIL
810 820 830 840 850
VGKVTPKGET ELTPEERLLR AIFGEKAREV RDTSLKVPHG ESGKVIGIRV
860 870 880 890 900
FSREDDDELP AGVNELVRVY VAQKRKISDG DKLAGRHGNK GVIGKILPAE
910 920 930 940 950
DMPFLPDGTP VDIILNTHGV PRRMNIGQIL ETHLGWVAKS GWNIDVANGV
960 970 980 990 1000
PEWAGKLPEN LLSAQPDSIV STPVFDGAQE AELQGLLSAT LPNRDGEVLV
1010 1020 1030 1040 1050
DGDGKAKLFD GRSGEPFPYP VTVGYMYIMK LHHLVDDKIH ARSTGPYSMI
1060 1070 1080 1090 1100
TQQPLGGKAQ FGGQRFGEME CWAMQAYGAA YTLQELLTIK SDDTVGRVKV
1110 1120 1130 1140 1150
YEAIVKGENI PEPGIPESFK VLLKELQSLC LNVEVLSSDG AAIELREGED
1160 1170
EDLERAAANL GINLSRNESA SVEDLA
Length:1,176
Mass (Da):129,548
Last modified:June 10, 2008 - v1
Checksum:i185C69A75D61A000
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC39451.1.

Genome annotation databases

EnsemblBacteriaiACC39451; ACC39451; MMAR_0995.
KEGGimmi:MMAR_0995.
PATRICi18062747. VBIMycMar75906_1062.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC39451.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216594.MMAR_0995.

Proteomic databases

PRIDEiB2HSJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACC39451; ACC39451; MMAR_0995.
KEGGimmi:MMAR_0995.
PATRICi18062747. VBIMycMar75906_1062.

Phylogenomic databases

eggNOGiENOG4108IIJ. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiEOG6M9DS6.

Enzyme and pathway databases

BioCyciMMAR216594:GJOB-998-MONOMER.

Family and domain databases

Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
HAMAPiMF_01321. RNApol_bact_RpoB.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 3 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-535 / M.

Entry informationi

Entry nameiRPOB_MYCMM
AccessioniPrimary (citable) accession number: B2HSJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: July 6, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.