B2HS83 (B2HS83_MYCMM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Pyrroline-5-carboxylate dehydrogenase, RocA EMBL ACC42661.1

Gene names

Name:	rocA EMBL ACC42661.1
Ordered Locus Names:	MMAR_4253

Organism

Mycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]

Taxonomic identifier

216594 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	543 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the aldehyde dehydrogenase family. RuleBase RU003345

Ontologies

Keywords
Molecular function	Oxidoreductase RuleBase RU003344
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: InterPro
Molecular function	1-pyrroline-5-carboxylate dehydrogenase activity Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B2HS83 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: BB509C997FA8A103	FASTA	543	58,560
	10 20 30 40 50 60 MDAITQVPIP ANEPVHSYAP HSPERSRLKS ELIALAQQPI DLPHVIGGKH RMGDGERIDV 70 80 90 100 110 120 VQPHRHAERL GTLTNAVHAD ATAAIEAAMA AKNGWAAMPF DERAGVFLRA ADLLAGPWRE 130 140 150 160 170 180 KIAAATMLGQ SKSAYQAEID APCELVDFWR FNVAFARQIL DQQPVSAKGE WNRTDHRPLE 190 200 210 220 230 240 GFVYAITPFN FTAIAANLPT APALMGNTVV WKPSVTQTLA AYLTMQALEA AGLPPGVINL 250 260 270 280 290 300 VTGDGLAVSD VALTDPRLAG IHFTGSTATF QHLWQQVGAN IASYQSYPRL VGETGGKDFV 310 320 330 340 350 360 VAHSSARPEV VATALIRGAF EYQGQKCSAA SRAFIPHSVW QQMGDTFLDT AAGLKYGDIT 370 380 390 400 410 420 DLSNFGGALI DRRAFIKNVD AIERAKGAAG VTIAVGGEYD DSVGYFVRPT VLLSDDPTDE 430 440 450 460 470 480 SFATEYFGPV LSLHVYPDDQ YERILDVIDT GSRYALTGAV IADDRNAVLT AQNRLRFAAG 490 500 510 520 530 540 NFYINDKPTG AVVGRQPFGG SRGSGTNDKA GSPQNLLRWT STRTIKETFV PATDHTYPHM ESD

References

[1]

"Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis." Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K., Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C., Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K., Lord A., Moule S. , Mungall K., Norbertczak H., Quail M.A., Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R., Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T. Genome Res. 18:729-741(2008) [PubMed: 18403782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000854 Genomic DNA. Translation: ACC42661.1.
RefSeq	YP_001852516.1. NC_010612.1.
3D structure databases
ProteinModelPortal	B2HS83.
ModBase	Search...
Protein-protein interaction databases
STRING	B2HS83.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000034168; EBMYCP00000032608; EBMYCG00000034163.
GeneID	6228535.
GenomeReviews	Gene locus MMAR_4253 in contig CP000854_GR.
KEGG	mmi:MMAR_4253.
PATRIC	18069799. VBIMycMar75906_4566.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000015660.
HOGENOM	HBG752218.
OMA	CELVDFW.
ProtClustDB	CLSK871904.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR005931. Delta1-pyrroline-5-COlate_DH-1. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KO	K00294.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR01236. D1pyr5carbox1. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B2HS83_MYCMM

Accession

Primary (citable) accession number: B2HS83

Entry history

Integrated into UniProtKB/TrEMBL:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)