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Protein

Glucose-1-phosphate adenylyltransferase

Gene

glgC

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of ADP-glucose, a building block, required in the biosynthesis of maltose-1-phosphate (M1P) and in the elongation reactions to produce linear alpha-1,4-glucans. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.UniRule annotation

Catalytic activityi

ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose.UniRule annotation

Pathwayi: capsule polysaccharide biosynthesis

This protein is involved in the pathway capsule polysaccharide biosynthesis, which is part of Capsule biogenesis.Curated
View all proteins of this organism that are known to be involved in the pathway capsule polysaccharide biosynthesis and in Capsule biogenesis.

Pathwayi: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99Alpha-D-glucose 1-phosphateUniRule annotation1
Binding sitei164Alpha-D-glucose 1-phosphate; via amide nitrogenUniRule annotation1
Binding sitei197Alpha-D-glucose 1-phosphate; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processCarbohydrate metabolism, Glycogen biosynthesis, Glycogen metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00164
UPA00934

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-1-phosphate adenylyltransferaseUniRule annotation (EC:2.7.7.27UniRule annotation)
Alternative name(s):
ADP-glucose pyrophosphorylaseUniRule annotation
Short name:
ADPGlc PPaseUniRule annotation
ADP-glucose synthaseUniRule annotation
Gene namesi
Name:glgCUniRule annotation
Ordered Locus Names:MMAR_4225
OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
Taxonomic identifieri216594 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000001190 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001304921 – 404Glucose-1-phosphate adenylyltransferaseAdd BLAST404

Proteomic databases

PRIDEiB2HS55

Interactioni

Protein-protein interaction databases

STRINGi216594.MMAR_4225

Structurei

3D structure databases

ProteinModelPortaliB2HS55
SMRiB2HS55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni179 – 180Alpha-D-glucose 1-phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QQ4 Bacteria
COG0448 LUCA
HOGENOMiHOG000278607
KOiK00975
OMAiHCVLGVR
OrthoDBiPOG091H09L2

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00624 GlgC, 1 hit
InterProiView protein in InterPro
IPR011831 ADP-Glc_PPase
IPR005836 ADP_Glu_pyroP_CS
IPR023049 GlgC_bac
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF00483 NTP_transferase, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
SSF53448 SSF53448, 2 hits
TIGRFAMsiTIGR02091 glgC, 1 hit
PROSITEiView protein in PROSITE
PS00808 ADP_GLC_PYROPHOSPH_1, 1 hit
PS00809 ADP_GLC_PYROPHOSPH_2, 1 hit
PS00810 ADP_GLC_PYROPHOSPH_3, 1 hit

Sequencei

Sequence statusi: Complete.

B2HS55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREAPHVLGI VLAGGEGKRL YPLTADRAKP AVPFGGAYRL IDFVLSNLVN
60 70 80 90 100
ARYLRICVLT QYKSHSLDRH ISQNWRLSGL AGEYITPVPA QQRLGPRWYT
110 120 130 140 150
GSADAIYQSL NLIYDEDPDY IVVFGADHVY RMDPEQMVRF HIDSGAGVTV
160 170 180 190 200
AGIRVPRADA SAFGCIDADD AGTIRDFVEK PLEPPGTPDD PTSTFVSMGN
210 220 230 240 250
YVFTTKVLID AIRADADDDH SDHDMGGDII PRLVADGMAA VYDFSNNEVP
260 270 280 290 300
GATDRDRAYW RDVGTLDAFY DAHMDLVSVH PVFNLYNKRW PIRGESENLA
310 320 330 340 350
PAKFVNGGSA QESVVGAGSI ISAASVRNSV LSSNVVVEDG AIVEGSVIMP
360 370 380 390 400
GARVGRGAVV RHAILDKNVV VGPGEMVGVD LDKDRERFAI SAGGVVAVGK

GVWI
Length:404
Mass (Da):43,627
Last modified:June 10, 2008 - v1
Checksum:i8092ADFF4B7140F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA Translation: ACC42633.1
RefSeqiWP_012395797.1, NC_010612.1

Genome annotation databases

EnsemblBacteriaiACC42633; ACC42633; MMAR_4225
GeneIDi34341240
KEGGimmi:MMAR_4225

Similar proteinsi

Entry informationi

Entry nameiGLGC_MYCMM
AccessioniPrimary (citable) accession number: B2HS55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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