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B2HRM4 (FABH_MYCMM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
EC=2.3.1.180
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III
Beta-ketoacyl-ACP synthase III
Short name=KAS III
Gene names
Name:fabH
Ordered Locus Names:MMAR_0879
OrganismMycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]
Taxonomic identifier216594 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815

Subunit structure

Homodimer By similarity. HAMAP MF_01815

Subcellular location

Cytoplasm By similarity HAMAP MF_01815.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3353353-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
PRO_1000187880

Regions

Region259 – 2635ACP-binding By similarity

Sites

Active site1221 By similarity
Active site2581 By similarity
Active site2891 By similarity

Sequences

Sequence LengthMass (Da)Tools
B2HRM4 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: A6E11F40DFD07868

FASTA33534,779
        10         20         30         40         50         60 
MTEIATTSGI SSVGLLSVGA YRPTRVVTND EICENIDSSD EWIYSRTGIK TRRFAAPEES 

        70         80         90        100        110        120 
AASMAIEASR EAIAKAALTG SDIDGVIVAT STHFLQTPAC APIVAAALGC QNVPAFDISA 

       130        140        150        160        170        180 
GCSGFGHALG IAADMIRGGS AATILVIGTE KLSPTVDMTD RSNCFIFADG AASVLVGHSP 

       190        200        210        220        230        240 
IQGIGPTVWG SDGEQAAAIR QDIDWISHAE NPAGPRPFLR MEGTAVFRWA AFEMGKVGQQ 

       250        260        270        280        290        300 
AMDAAGVKPD EIDVFIPHQA NSRINELLTK NLQLRPDAVI ANDIEHTGNT SAASIPLAMA 

       310        320        330 
ELLATGAAKP GDLALLIGYG AGLSYAAQVV RMPNS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000854 Genomic DNA. Translation: ACC39336.1.
RefSeqYP_001849191.1. NC_010612.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB2HRM4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000034158; EBMYCP00000032598; EBMYCG00000034153.
GeneID6225127.
GenomeReviewsGene locus MMAR_0879 in contig CP000854_GR.
KEGGmmi:MMAR_0879.
PATRIC18062495. VBIMycMar75906_0940.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016069.
HOGENOMHBG649927.
OMASNCFIFA.
ProtClustDBPRK09352.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK11608.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFABH_MYCMM
AccessionPrimary (citable) accession number: B2HRM4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 10, 2008
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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