B2HRH1 (B2HRH1_MYCMM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Alpha-ketoglutarate decarboxylase Kgd EMBL ACC42602.1

Gene names

Name:	kgd EMBL ACC42602.1
Ordered Locus Names:	MMAR_4194

Organism

Mycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]

Taxonomic identifier

216594 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	1251 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family. RuleBase RU003423

Ontologies

Keywords
Ligand	Thiamine pyrophosphate SAAS SAAS001017
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: InterPro thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro transferase activity, transferring acyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B2HRH1 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 23833D7C2F42EC08	FASTA	1,251	138,032
	10 20 30 40 50 60 MRRTAAVANI SSPFGQNEWL VEEMYRKFRD DPSSVDPSWH EFLVDYNPES TQEATEPAVE 70 80 90 100 110 120 KPAVAPAKPA AAPAKPAPAP APAKPAAGPP AAGNGSPAAA PSAKPAAAPA KAPAPPPAEG 130 140 150 160 170 180 DEMQVLRGAA AAVVKNMSAS LDVPTATSVR AVPAKLLIDN RIVINNQLKR NRGGKISFTH 190 200 210 220 230 240 LLGYALVQAV KKFPNMNRHY LDVDGKPNAV TPAHTNLGLA IDLQGKDGKR ALVVAGIKRC 250 260 270 280 290 300 ETMRFAQFVT AYEDIVRRAR DGKLTAEDFS GVTISLTNPG TIGTVHSVPR LMAGQGAIIG 310 320 330 340 350 360 VGAMEYPAEF QGASEERIAE LGIGKLITLT STYDHRIIQG AESGDFLRTI HQMLLADEFW 370 380 390 400 410 420 DEIFRELSIP YLPVRWRPDN PDSIVDKNAR IIELIAAYRN RGHLMADIDP LRLDKTRFRS 430 440 450 460 470 480 HPDLDVCTHG LTLWDLDRSF KVGGCFAGPQ NMKLRDVLSI LRDAYCRHVG VEYTHILEPE 490 500 510 520 530 540 QQQWLQQRVE AKHVKPTVAQ QKYVLSKLNA AEAFETFLQT KYVGQKRFSL EGAESVIPMM 550 560 570 580 590 600 DAAIDQCAEY GLDEVVIGMP HRGRLNVLAN IVGKPYSQIF SEFEGNLNPS QAHGSGDVKY 610 620 630 640 650 660 HLGATGVYLQ MFGDNDIQVS LTANPSHLEA VDPVLEGLVR AKQDLLEHGE TDTENQRAFS 670 680 690 700 710 720 VVPMMLHGDA AFAGQGVVAE TLNLANLPGY RVGGTIHIIV NNQIGFTTAP EYSRSTEYCT 730 740 750 760 770 780 DVAKTIGAPI FHVNGDDPEA CVWVARLAVD FRQRFNKDVI IDMLCYRRRG HNEGDDPSMT 790 800 810 820 830 840 NPRMYDVVDT KRGVRKSYTE ALIGRGDISI KEAEDALRDY QGQLEQVFNE VRELEKHGAQ 850 860 870 880 890 900 PSESVESDQM IPAGLATAVD KSLLARIGDA FLAVPDGFTT HPRVQPVLEK RREMAYEGKI 910 920 930 940 950 960 DWAFAELLAL GSLVAEGKLV RFSGQDTRRG TFSQRHSVII DRHTREEFTP LQLLTTNKDG 970 980 990 1000 1010 1020 SPTGGKFLVY DSPLSEYAAV GFEYGYTVGN PDAVVLWEAQ FGDFVNGAQS IIDEFISSGE 1030 1040 1050 1060 1070 1080 AKWGQLSNVV LLLPHGHEGQ GPDHTSGRIE RFLQLWAEGS MTIAMPSTPS NYFHLLRRHA 1090 1100 1110 1120 1130 1140 LDGIQRPLIV FTPKSMLRNK AAVSDIKDFT EIKFRSVLEE PTYEDGVGDR NLVNRILLTS 1150 1160 1170 1180 1190 1200 GKIYYEMVAR KAKDKREDVA IVRVEQLAPL PRRRLRETLD RYPNAKEFFW VQEEPANQGA 1210 1220 1230 1240 1250 WPRFGLELPE LLPEKLSGVK RISRRAMSAP SSGSSKVHAV EQQEILDTAF G

References

[1]

"Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis." Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K., Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C., Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K., Lord A., Moule S. , Mungall K., Norbertczak H., Quail M.A., Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R., Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T. Genome Res. 18:729-741(2008) [PubMed: 18403782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000854 Genomic DNA. Translation: ACC42602.1.
RefSeq	YP_001852457.1. NC_010612.1.
3D structure databases
ProteinModelPortal	B2HRH1.
ModBase	Search...
Protein-protein interaction databases
STRING	B2HRH1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000032394; EBMYCP00000030834; EBMYCG00000032389.
GeneID	6228476.
GenomeReviews	Gene locus MMAR_4194 in contig CP000854_GR.
KEGG	mmi:MMAR_4194.
PATRIC	18069673. VBIMycMar75906_4503.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000014858.
HOGENOM	HBG289950.
OMA	EGDEPAF.
ProtClustDB	PRK12270.
Family and domain databases
InterPro	IPR001078. 2-oxoacid_DH_actylTfrase. IPR011603. 2oxoglutarate_DH_E1. IPR023213. CAT-like_dom. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
Gene3D	G3DSA:3.30.559.10. CAT-like_dom. 1 hit.
KO	K01616.
PANTHER	PTHR23152. 2oxoglutarate_DH_E1. 1 hit.
Pfam	PF00198. 2-oxoacid_dh. 1 hit. PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B2HRH1_MYCMM

Accession

Primary (citable) accession number: B2HRH1

Entry history

Integrated into UniProtKB/TrEMBL:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)