B2HR26 (B2HR26_MYCMM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150
Short name=AGPR HAMAP MF_00150
EC=1.2.1.38 HAMAP MF_00150

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase HAMAP MF_00150

Gene names

Name:	argC HAMAP MF_00150 EMBL ACC40912.1
Ordered Locus Names:	MMAR_2462

Organism

Mycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]

Taxonomic identifier

216594 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150 SAAS SAAS023013
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate. RuleBase RU004258 Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150 SAAS SAAS023013
Subcellular location	Cytoplasm By similarity HAMAP MF_00150 SAAS SAAS023013.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. HAMAP MF_00150

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis HAMAP MF_00150 SAAS SAAS023013
Cellular component	Cytoplasm HAMAP MF_00150 SAAS SAAS023013
Ligand	NADP HAMAP MF_00150 SAAS SAAS023013
Molecular function	Oxidoreductase HAMAP MF_00150 SAAS SAAS023013
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	156	1	By similarity HAMAP MF_00150

Sequences

	Sequence		Length	Mass (Da)
	B2HR26 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: B49F469321CBDDA4	FASTA	350	36,249
	10 20 30 40 50 60 MAHATDAIRV AVAGASGYAG GEILRLLLGH PAYTSGRLTI GAVTAAASAG SVLAEHHPHL 70 80 90 100 110 120 LPLAQRILEP TELEVLRGHD VVFLALPHGH SAALADQLGP ETLIIDCGAD FRLTDAAAWE 130 140 150 160 170 180 RFYGSAHSGS WPYGLPELPG ARERLRDTRR IAVPGCYPTA ALLALLPAVA EGLIDPAVTV 190 200 210 220 230 240 VAVSGTSGAG RAAKTDLLGS EVIGSARAYN IAGAHRHTPE IAQGLRAVTD RDVTVSFTPV 250 260 270 280 290 300 LIPTSRGILA TCTARTRSPI ARLRSAYEKA YEAEPFIYLM PEGQLPRTGA VIGSNAAHIA 310 320 330 340 350 VAVDEEAETF VAIAAIDNLV KGTAGAAVQS MNLALGWPET EGLSVVGVAP

References

[1]

"Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis." Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K., Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C., Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K., Lord A., Moule S. , Mungall K., Norbertczak H., Quail M.A., Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R., Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T. Genome Res. 18:729-741(2008) [PubMed: 18403782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000854 Genomic DNA. Translation: ACC40912.1.
RefSeq	YP_001850767.1. NC_010612.1.
3D structure databases
ProteinModelPortal	B2HR26.
ModBase	Search...
Protein-protein interaction databases
STRING	B2HR26.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000031173; EBMYCP00000029613; EBMYCG00000031168.
GeneID	6226728.
GenomeReviews	Gene locus MMAR_2462 in contig CP000854_GR.
KEGG	mmi:MMAR_2462.
PATRIC	18065885. VBIMycMar75906_2623.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000015828.
HOGENOM	HBG294213.
OMA	SHFSWRN.
ProtClustDB	PRK00436.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B2HR26_MYCMM

Accession

Primary (citable) accession number: B2HR26

Entry history

Integrated into UniProtKB/TrEMBL:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)