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B2HQL6 (B2HQL6_MYCMM) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homoserine kinase HAMAP MF_00384
Short name=HK HAMAP MF_00384
Short name=HSK HAMAP MF_00384
EC=2.7.1.39 HAMAP MF_00384
Gene names
Name:thrB HAMAP MF_00384 EMBL ACC42508.1
Ordered Locus Names:MMAR_4101
OrganismMycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]
Taxonomic identifier216594 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384 SAAS SAAS006203

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384 SAAS SAAS006203

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384 SAAS SAAS006203

Subcellular location

Cytoplasm By similarity HAMAP MF_00384 SAAS SAAS006203.

Sequence similarities

Belongs to the GHMP kinase family. RuleBase RU004209

Belongs to the GHMP kinase family. Homoserine kinase subfamily. HAMAP MF_00384

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding95 – 10511ATP By similarity HAMAP MF_00384

Sequences

Sequence LengthMass (Da)Tools
B2HQL6 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: AB2C18BC6A9A7161

FASTA31432,566
        10         20         30         40         50         60 
MTQVLPSGLV ASAVVAASSA NLGPGFDSLG LALSLYDEIV LETTDSGLEV VVEGEGSGQV 

        70         80         90        100        110        120 
PLNSEHLVVR AIQHGLRAVG VSAAGLIVRC RNDIPHSRGL GSSASAVVGG LAAVNGLVSQ 

       130        140        150        160        170        180 
AGWAPLSDQQ LIQLSSEFEG HPDNAAAAVL GGAVVSWIER CGDRADYSAV QLDLHPDIHL 

       190        200        210        220        230        240 
FSAIPEVRSS TAETRVLLPD LVSHDDARFN ISRAALLVVA LTQRPDLLMA ATEDVLHQPQ 

       250        260        270        280        290        300 
RASAMPASAE YLQLLRRHKV AATLSGAGPA LIALSTDPDL PPEAVEYGAA NGFTITAMTA 

       310 
GDRVRWKPGV AFSD

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000854 Genomic DNA. Translation: ACC42508.1.
RefSeqYP_001852363.1. NC_010612.1.

3D structure databases

ProteinModelPortalB2HQL6.
ModBaseSearch...

Protein-protein interaction databases

STRINGB2HQL6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000035744; EBMYCP00000034184; EBMYCG00000035739.
GeneID6228380.
GenomeReviewsGene locus MMAR_4101 in contig CP000854_GR.
KEGGmmi:MMAR_4101.
PATRIC18069453. VBIMycMar75906_4394.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016145.
HOGENOMHBG646290.
OMADRLHQPY.
ProtClustDBPRK01212.

Family and domain databases

HAMAPMF_00384. Homoser_kinase.
[Tree]
InterProIPR006204. GHMP_kinase.
IPR013750. GHMP_kinase_C.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
Gene3DG3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KOK00872.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
PRINTSPR00958. HOMSERKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00191. ThrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB2HQL6_MYCMM
AccessionPrimary (citable) accession number: B2HQL6
Entry history
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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