B2HQ75 (B2HQ75_MYCMM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
DNA polymerase III, alpha subunit, DnaE1 EMBL ACC40818.1

Gene names

Name:	dnaE1 EMBL ACC40818.1
Ordered Locus Names:	MMAR_2369

Organism

Mycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]

Taxonomic identifier

216594 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	1180 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). SAAS SAAS004013

Ontologies

Keywords
Biological process	DNA replication SAAS SAAS004013
Cellular component	Cytoplasm SAAS SAAS004013
Molecular function	DNA-directed DNA polymerase SAAS SAAS004013 Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B2HQ75 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: DAA7830CF116B168	FASTA	1,180	129,123
	10 20 30 40 50 60 MSGSSSRSFV HLHNHTEYSM LDGAAKITPM LAEVERLDMP AIGMTDHGNM FGASEFYNSA 70 80 90 100 110 120 TKAGVKPIIG VEAYVAPGSR FDTRRITWGD PSQKGDDVSG SGSYTHLTMV AENATGLRNL 130 140 150 160 170 180 FKLSSLASFE GQLGKWSRMD AELVAEHAEG IIATTGCPSG EVQTRLRLGH DREALESAAK 190 200 210 220 230 240 WREIFGADNY FLELMDHGLS IERRVREGLI EIGRKLDIPP LATNDCHYVT RDAAHNHEAL 250 260 270 280 290 300 LCVQTGKTLS DPNRFKFDGD GYYLKSAAEM RQLWDDDIPG ACDSTLLIAE RVQSYADVWT 310 320 330 340 350 360 PRDRMPIFPV PEGHDPASWL HHEVMAGLRR RFPSGLGQDY IDRAEYEIKV ICDKGFPSYF 370 380 390 400 410 420 LIVADLINYA RSVDIRVGPG RGSAAGSLVA YAMGITNIDP IPHGLLFERF LNPERPSAPD 430 440 450 460 470 480 IDIDFDDRRR GEMVRYAADK WGQDRVAQVI TFGTIKTKAA LKDSARIHYG QPGFAIADRI 490 500 510 520 530 540 TKALPPPIMA KDIPLSGITD PAHERFKEAA EVRGLIETDP DVRTIYQTAR GLEGLIRNAG 550 560 570 580 590 600 VHACAVIMSS EPLTEAIPLW KRPQDGAIIT GWDYPSCEAI GLLKMDFLGL RNLTIIGDAI 610 620 630 640 650 660 ENIKANRGID LDLESLPLDD KPTYELLGRG ETLGVFQLDG GPMRDLLRRM QPTEFNDIVA 670 680 690 700 710 720 VLALYRPGPM GMNAHNDYAD RKNNRQAVKP IHPELEEPLR EILSETYGLI VYQEQIMFIA 730 740 750 760 770 780 QKVASYTMGK ADALRKAMGK KKLEVLEAEY KGFYEGMTAN GFSEKAVKAL WDTILPFAGY 790 800 810 820 830 840 AFNKSHAAGY GLVSYWTAYL KANYPAEYMA GLLTSVGDDK DKAAVYLADC RKLGITVLPP 850 860 870 880 890 900 DVNESLVNFA SVGQDIRFGL GAVRNVGANV VGSLIGTRSG KGKFTDFSDY LNKIDISACN 910 920 930 940 950 960 KKVTESLIKA GAFDSLGHPR KGLFLVHTDA VDSVLGTKKA EAMGQFDLFG GSDSGADAVF 970 980 990 1000 1010 1020 TIKVPEDEWE DKHKLALERE MLGLYVSGHP LNGVAHLLAA QVDTAIPAIL DGDVSNDAQV 1030 1040 1050 1060 1070 1080 RVGGILAAVN RRVNKNGMPW ASAQLEDLTG GIEVMFFPHT YSNYGADIAD DAVVLVNAKV 1090 1100 1110 1120 1130 1140 AIRDDRISLI ANELVVPDFS NAQADRPLAV SLPTRQCTID KVTALKQVLA RHPGTSQVHL 1150 1160 1170 1180 RLISGDRITT LELDQSLRVT PSPALMGDLK ELLGPGCLGS

References

[1]

"Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis." Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K., Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C., Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K., Lord A., Moule S. , Mungall K., Norbertczak H., Quail M.A., Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R., Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T. Genome Res. 18:729-741(2008) [PubMed: 18403782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000854 Genomic DNA. Translation: ACC40818.1.
RefSeq	YP_001850673.1. NC_010612.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B2HQ75.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000032436; EBMYCP00000030876; EBMYCG00000032431.
GeneID	6226633.
GenomeReviews	Gene locus MMAR_2369 in contig CP000854_GR.
KEGG	mmi:MMAR_2369.
PATRIC	18065687. VBIMycMar75906_2525.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016568.
HOGENOM	HBG734490.
OMA	RVLQMPY.
ProtClustDB	PRK05673.
Family and domain databases
InterPro	IPR011708. DNA_pol3_alpha. IPR004365. NA-bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. Pol/His_phosphatase_N. IPR016195. Pol/histidinol_Pase-like. IPR004805. PolC_alpha. [Graphical view]
KO	K02337.
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
TIGRFAMs	TIGR00594. Polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B2HQ75_MYCMM

Accession

Primary (citable) accession number: B2HQ75

Entry history

Integrated into UniProtKB/TrEMBL:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)