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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei161 – 1611UniRule annotation
Active sitei593 – 5931UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciMMAR216594:GJOB-2262-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
Ordered Locus Names:MMAR_2247Imported
OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)Imported
Taxonomic identifieri216594 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000001190 Componenti: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi216594.MMAR_2247.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2HP92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEVSDTALE PIGDVHRTRI GREATEPMRA DIRLLGAILG DTVREQNGDE
60 70 80 90 100
VFELVERARV EAFRVRHSEI DRAEMARMFE GIDIHHAIPI IRAFSHFALL
110 120 130 140 150
ANVAEDIHRE RRRSIHVAAG EPPQDSSLAA TYMKLDAAQL DSATIAEALK
160 170 180 190 200
GALVSPVITA HPTETRRRTI FETQHRITQL MRLHAEGHTE TDDGRGIEVE
210 220 230 240 250
LRRQVLRLWQ TALIRLFRLQ ISDEIEVGLR YYPAALFEVI PQVNAEVRDA
260 270 280 290 300
LRARWPDADL LSEPILRPGS WIGGDRDGNP NVTAEVVRLA TGSAAFTALA
310 320 330 340 350
HYLAELTALA QELSMSARLI TVTPELATLA DACPAGARPD EPYRRALQVV
360 370 380 390 400
RGRLSATAAE ILDQQPQHTL ELGLPPYATA AELRADLDTI DASLHNHGAG
410 420 430 440 450
LLADDRLARL REAVRVFGFH LSGLDMRQNS DVHEQVVGEL LAWAGVHPDY
460 470 480 490 500
TSLAEAERVE LLAAELSTRR PLIRDGAQLS DLARSELGVL AAAAHAVWTF
510 520 530 540 550
GPAAVPNYII SMCRSVSDML EAAVLLKEVG LLDASESEPY CPVGISPLFE
560 570 580 590 600
TIEDLHNGAA ILQAMLDLPL YRALVTARGG CQEVMLGYSD SNKDGGYLAA
610 620 630 640 650
NWAVYRAELA LVETARKTGI RLRLFHGRGG TVGRGGGPSY QAILAQPPGA
660 670 680 690 700
VSGSLRLTEQ GEVIAAKYAE PQMARRNLES LLAATLESTL LDVEGLGDTA
710 720 730 740 750
APAYAVLDEV AALAQRAYAE LVHETPGFVE YFKASTPVSE IGALNIGSRP
760 770 780 790 800
TSRKPTASIA DLRAIPWVLA WSQSRVMLPG WYGTGSAFEQ WLAAGPESEA
810 820 830 840 850
DRLQVLHDLY QRWPFFRSVL SNMAQVMAKS DLELAARYSE LVADETLRRR
860 870 880 890 900
VFDKIADEHH RTIAMYKRIT GQDDLLADNP ALARSVFNRF PYLEPLNHLQ
910 920 930
VELLRRYRSG EDDESVQRGI LLTMNGLASA LRNSG
Length:935
Mass (Da):102,668
Last modified:June 9, 2008 - v1
Checksum:iA25AC95BF2D2A2C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC40696.1.
RefSeqiYP_001850551.1. NC_010612.1.

Genome annotation databases

EnsemblBacteriaiACC40696; ACC40696; MMAR_2247.
KEGGimmi:MMAR_2247.
PATRICi18065435. VBIMycMar75906_2399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC40696.1.
RefSeqiYP_001850551.1. NC_010612.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216594.MMAR_2247.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACC40696; ACC40696; MMAR_2247.
KEGGimmi:MMAR_2247.
PATRICi18065435. VBIMycMar75906_2399.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciMMAR216594:GJOB-2262-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-535 / MImported.

Entry informationi

Entry nameiB2HP92_MYCMM
AccessioniPrimary (citable) accession number: B2HP92
Entry historyi
Integrated into UniProtKB/TrEMBL: June 9, 2008
Last sequence update: June 9, 2008
Last modified: March 31, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.