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Protein

UvrABC system protein C

Gene

uvrC

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:MMAR_2227
OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
Taxonomic identifieri216594 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000001190 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000995021 – 647UvrABC system protein CAdd BLAST647

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi216594.MMAR_2227.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 95GIY-YIGUniRule annotationAdd BLAST80
Domaini208 – 243UVRUniRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation
Contains 1 GIY-YIG domain.UniRule annotation
Contains 1 UVR domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CII. Bacteria.
COG0322. LUCA.
HOGENOMiHOG000279962.
KOiK03703.
OMAiRCPGVCQ.
OrthoDBiPOG091H01BS.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC. 1 hit.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2HP72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDPATYRPA PGSIPVEPGV YRFRDPHGRV IYVGKAKSLR SRLTSYFADI
60 70 80 90 100
AHLQPRTRQM VTTAAKVEWT VVNTEVEALQ LEYNWIKEFD PRFNVRYRDD
110 120 130 140 150
KSYPVLAVTL NEDFPRLMVY RGPRRKGVRY FGPYSHAWAI RETVDLLTRV
160 170 180 190 200
FPARTCSMGV FKRHKQIDRP CLLGYIDKCS APCIGRVSKE QHRQIVDDFC
210 220 230 240 250
DFLSGKTDRY ARELEQQMNA AAENLDFERA ARLRDDRSAL KRAMEKQAVV
260 270 280 290 300
LGDGTDADVV AFADDELEAA VQVFHVRGGR VRGQRGWVVE KPSAPDVSVE
310 320 330 340 350
EQLVEQFLAQ FYGDQAELGG AADESVNPVP REVLVPCLPS NADQLSSWLS
360 370 380 390 400
GLRGSRVTLR VPRRGDKRAL AETVQRNAKE ALQQHKLKRA GDFNARSAAL
410 420 430 440 450
QNIQEALGLA DAPLRIECVD ISHVQGTDVV ASLVVFEDGL PRKSDYRHFA
460 470 480 490 500
IREAAGQGRS DDVASIAEVT RRRFQRHLSE QNDPNLLSPE GKSRRFAYPP
510 520 530 540 550
NLYVVDGGAP QVNAASAVLE ELGIVDVAVI GLAKRLEEVW VPSEPDPIIM
560 570 580 590 600
PRNSEGLYLL QRVRDEAHRF AITYHRSKRS KRMTASALDA VPGLGEHRRK
610 620 630 640
ALVTHFGSIA RLKEATVDQI TAVPGIGVAT ATAVLEALRP DQPGGAQ
Length:647
Mass (Da):72,165
Last modified:June 10, 2008 - v1
Checksum:iCCDA686267DB0C90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC40676.1.
RefSeqiWP_012393990.1. NC_010612.1.

Genome annotation databases

EnsemblBacteriaiACC40676; ACC40676; MMAR_2227.
KEGGimmi:MMAR_2227.
PATRICi18065393. VBIMycMar75906_2378.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC40676.1.
RefSeqiWP_012393990.1. NC_010612.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216594.MMAR_2227.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACC40676; ACC40676; MMAR_2227.
KEGGimmi:MMAR_2227.
PATRICi18065393. VBIMycMar75906_2378.

Phylogenomic databases

eggNOGiENOG4105CII. Bacteria.
COG0322. LUCA.
HOGENOMiHOG000279962.
KOiK03703.
OMAiRCPGVCQ.
OrthoDBiPOG091H01BS.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC. 1 hit.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUVRC_MYCMM
AccessioniPrimary (citable) accession number: B2HP72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: November 2, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.