B2HP45 (PYRF_MYCMM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Orotidine 5'-phosphate decarboxylase
EC=4.1.1.23

Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase

Gene names

Name:	pyrF
Ordered Locus Names:	MMAR_2200

Organism

Mycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]

Taxonomic identifier

216594 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium marinum

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01215
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01215
Sequence similarities	Belongs to the OMP decarboxylase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' UMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway 'de novo' pyrimidine nucleobase biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	orotidine-5'-phosphate decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01215		PRO_1000213894
Sites
	Active site	95	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2HP45 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 65F60EDB8D5E794D	FASTA	278	27,837
	10 20 30 40 50 60 MTGFGARLAE AKAHRGPLCL GIDPHPELLR AWDLPATADG LAAFCDICVA AFAGFAVVKP 70 80 90 100 110 120 QVAFFEAYGA AGFAVLEGTM AALRANGVLV LADAKRGDIG STMAAYAAAW AGDSPLAADA 130 140 150 160 170 180 VTVSPFLGFG SLRPLLEVAT ANDRGVFVLA ATSNPEGATI QRADADGRTV AQLIVDQVGL 190 200 210 220 230 240 FNSEVGEVTG PEPGSVGVVV GATVLNPPDV SGLGGPVLVP GVGVQGGRPE ALGGLGGAAP 250 260 270 QQLLPAVSRE VLRAGPSISE VRAAAERMLD SVAYLSAV

References

[1]

"Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis." Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K., Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C., Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K., Lord A., Moule S. , Mungall K., Norbertczak H., Quail M.A., Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R., Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T. Genome Res. 18:729-741(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-535 / M.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000854 Genomic DNA. Translation: ACC40649.1.
RefSeq	YP_001850504.1. NC_010612.1.
3D structure databases
ProteinModelPortal	B2HP45.
ModBase	Search...
Protein-protein interaction databases
STRING	216594.MMAR_2200.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACC40649; ACC40649; MMAR_2200.
GeneID	6226464.
KEGG	mmi:MMAR_2200.
PATRIC	18065339. VBIMycMar75906_2351.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0284.
HOGENOM	HOG000245748.
KO	K01591.
OMA	ERGPLCV.
ProtClustDB	PRK00125.
Enzyme and pathway databases
BioCyc	MMAR216594:GJOB-2215-MONOMER.
UniPathway	UPA00070; UER00120.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_01215. OMPdecase_type2.
InterPro	IPR013785. Aldolase_TIM. IPR018089. OMPdecase_AS. IPR011995. OMPdecase_type-2. IPR001754. OMPdeCOase_dom. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00215. OMPdecase. 1 hit. [Graphical view]
SMART	SM00934. OMPdecase. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMs	TIGR02127. pyrF_sub2. 1 hit.
PROSITE	PS00156. OMPDECASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRF_MYCMM

Accession

Primary (citable) accession number: B2HP45

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	June 10, 2008
Last modified:	May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program