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B2HNG9

- B2HNG9_MYCMM

UniProt

B2HNG9 - B2HNG9_MYCMM

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Protein
Submitted name: Formamidopyrimidine-DNA glycosylase
Gene
MMAR_3812
Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Removes damaged bases from DNA, leaving an abasic site.SAAS annotations
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.SAAS annotations

Cofactori

Binds 1 zinc ion per subunit By similarity.SAAS annotations

GO - Molecular functioni

  1. DNA-(apurinic or apyrimidinic site) lyase activity Source: InterPro
  2. damaged DNA binding Source: InterPro
  3. hydrolase activity, hydrolyzing N-glycosyl compounds Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. base-excision repair Source: InterPro
  2. nucleotide-excision repair Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseSAAS annotations, Hydrolase, LyaseSAAS annotations

Keywords - Biological processi

DNA damage, DNA repairSAAS annotations

Keywords - Ligandi

DNA-bindingSAAS annotations, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMMAR216594:GJOB-3837-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Formamidopyrimidine-DNA glycosylaseImported
Gene namesi
Ordered Locus Names:MMAR_3812Imported
OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)Imported
Taxonomic identifieri216594 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000001190: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi216594.MMAR_3812.

Family & Domainsi

Sequence similaritiesi

Contains FPG-type zinc finger.SAAS annotations

Keywords - Domaini

Zinc-fingerSAAS annotations

Phylogenomic databases

eggNOGiCOG0266.
HOGENOMiHOG000020880.
KOiK05522.
OMAiNVYRAEV.
OrthoDBiEOG6QP131.

Family and domain databases

InterProiIPR015886. DNA_glyclase/AP_lyase_DNA-bd.
IPR015887. DNA_glyclase_Znf_dom_DNA_BS.
IPR012319. DNA_glycosylase/AP_lyase_cat.
IPR010979. Ribosomal_S13-like_H2TH.
IPR000214. Znf_DNA_glyclase/AP_lyase.
IPR010663. Znf_DNA_glyclase/IsotRNA_synth.
[Graphical view]
PfamiPF01149. Fapy_DNA_glyco. 1 hit.
PF06831. H2TH. 1 hit.
PF06827. zf-FPG_IleRS. 1 hit.
[Graphical view]
SMARTiSM00898. Fapy_DNA_glyco. 1 hit.
[Graphical view]
SUPFAMiSSF46946. SSF46946. 1 hit.
SSF81624. SSF81624. 1 hit.
PROSITEiPS01242. ZF_FPG_1. 1 hit.
PS51066. ZF_FPG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2HNG9-1 [UniParc]FASTAAdd to Basket

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MPEGHTLHRL ARLHQRRFAG APVVVSSPQG KFADSAGAVD GRVLRAASAW    50
GKHLFHHYAG GPVVHVHLGL YGAFTEWARS AGELLPDPVG QVRMRMVGAE 100
YGTDLRGPTV CEVIDDAQVA DVLARLGPDP LRKDADPSWA WARIAKSRRP 150
IGALLMDQKV MAGVGNVYRS ELLFRHRIDP YRSGQRITEA EFSAAWTDLV 200
ALMKVGLRGG KIVVVRPEHD HGAPSYAAGR PRTYVYRRAG DPCRVCGATV 250
GTAVLEGRNV FWCPSCQA 268
Length:268
Mass (Da):29,203
Last modified:June 10, 2008 - v1
Checksum:i8F0DB320AE2A3764
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000854 Genomic DNA. Translation: ACC42222.1.
RefSeqiWP_012395412.1. NC_010612.1.
YP_001852077.1. NC_010612.1.

Genome annotation databases

EnsemblBacteriaiACC42222; ACC42222; MMAR_3812.
GeneIDi6228086.
KEGGimmi:MMAR_3812.
PATRICi18068817. VBIMycMar75906_4083.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000854 Genomic DNA. Translation: ACC42222.1 .
RefSeqi WP_012395412.1. NC_010612.1.
YP_001852077.1. NC_010612.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216594.MMAR_3812.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC42222 ; ACC42222 ; MMAR_3812 .
GeneIDi 6228086.
KEGGi mmi:MMAR_3812.
PATRICi 18068817. VBIMycMar75906_4083.

Phylogenomic databases

eggNOGi COG0266.
HOGENOMi HOG000020880.
KOi K05522.
OMAi NVYRAEV.
OrthoDBi EOG6QP131.

Enzyme and pathway databases

BioCyci MMAR216594:GJOB-3837-MONOMER.

Family and domain databases

InterProi IPR015886. DNA_glyclase/AP_lyase_DNA-bd.
IPR015887. DNA_glyclase_Znf_dom_DNA_BS.
IPR012319. DNA_glycosylase/AP_lyase_cat.
IPR010979. Ribosomal_S13-like_H2TH.
IPR000214. Znf_DNA_glyclase/AP_lyase.
IPR010663. Znf_DNA_glyclase/IsotRNA_synth.
[Graphical view ]
Pfami PF01149. Fapy_DNA_glyco. 1 hit.
PF06831. H2TH. 1 hit.
PF06827. zf-FPG_IleRS. 1 hit.
[Graphical view ]
SMARTi SM00898. Fapy_DNA_glyco. 1 hit.
[Graphical view ]
SUPFAMi SSF46946. SSF46946. 1 hit.
SSF81624. SSF81624. 1 hit.
PROSITEi PS01242. ZF_FPG_1. 1 hit.
PS51066. ZF_FPG_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-535 / M.

Entry informationi

Entry nameiB2HNG9_MYCMM
AccessioniPrimary (citable) accession number: B2HNG9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzymeSAAS annotations

External Data

Dasty 3

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