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B2HNG9

- B2HNG9_MYCMM

UniProt

B2HNG9 - B2HNG9_MYCMM

Protein
Submitted name:

Formamidopyrimidine-DNA glycosylase

Gene

MMAR_3812

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Removes damaged bases from DNA, leaving an abasic site.SAAS annotation
    The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.SAAS annotation

    Cofactori

    Binds 1 zinc ion per subunit.SAAS annotation

    GO - Molecular functioni

    1. damaged DNA binding Source: InterPro
    2. DNA-(apurinic or apyrimidinic site) lyase activity Source: InterPro
    3. hydrolase activity, hydrolyzing N-glycosyl compounds Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. base-excision repair Source: InterPro
    2. nucleotide-excision repair Source: InterPro

    Keywords - Molecular functioni

    GlycosidaseSAAS annotation, Hydrolase, LyaseSAAS annotation

    Keywords - Biological processi

    DNA damage, DNA repairSAAS annotation

    Keywords - Ligandi

    DNA-bindingSAAS annotation, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciMMAR216594:GJOB-3837-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Formamidopyrimidine-DNA glycosylaseImported
    Gene namesi
    Ordered Locus Names:MMAR_3812Imported
    OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)Imported
    Taxonomic identifieri216594 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000001190: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi216594.MMAR_3812.

    Family & Domainsi

    Sequence similaritiesi

    Contains FPG-type zinc finger.SAAS annotation

    Keywords - Domaini

    Zinc-fingerSAAS annotation

    Phylogenomic databases

    eggNOGiCOG0266.
    HOGENOMiHOG000020880.
    KOiK05522.
    OMAiNVYRAEV.
    OrthoDBiEOG6QP131.

    Family and domain databases

    InterProiIPR015886. DNA_glyclase/AP_lyase_DNA-bd.
    IPR015887. DNA_glyclase_Znf_dom_DNA_BS.
    IPR012319. DNA_glycosylase/AP_lyase_cat.
    IPR010979. Ribosomal_S13-like_H2TH.
    IPR000214. Znf_DNA_glyclase/AP_lyase.
    IPR010663. Znf_DNA_glyclase/IsotRNA_synth.
    [Graphical view]
    PfamiPF01149. Fapy_DNA_glyco. 1 hit.
    PF06831. H2TH. 1 hit.
    PF06827. zf-FPG_IleRS. 1 hit.
    [Graphical view]
    SMARTiSM00898. Fapy_DNA_glyco. 1 hit.
    [Graphical view]
    SUPFAMiSSF46946. SSF46946. 1 hit.
    SSF81624. SSF81624. 1 hit.
    PROSITEiPS01242. ZF_FPG_1. 1 hit.
    PS51066. ZF_FPG_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2HNG9-1 [UniParc]FASTAAdd to Basket

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    MPEGHTLHRL ARLHQRRFAG APVVVSSPQG KFADSAGAVD GRVLRAASAW    50
    GKHLFHHYAG GPVVHVHLGL YGAFTEWARS AGELLPDPVG QVRMRMVGAE 100
    YGTDLRGPTV CEVIDDAQVA DVLARLGPDP LRKDADPSWA WARIAKSRRP 150
    IGALLMDQKV MAGVGNVYRS ELLFRHRIDP YRSGQRITEA EFSAAWTDLV 200
    ALMKVGLRGG KIVVVRPEHD HGAPSYAAGR PRTYVYRRAG DPCRVCGATV 250
    GTAVLEGRNV FWCPSCQA 268
    Length:268
    Mass (Da):29,203
    Last modified:June 10, 2008 - v1
    Checksum:i8F0DB320AE2A3764
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000854 Genomic DNA. Translation: ACC42222.1.
    RefSeqiWP_012395412.1. NC_010612.1.
    YP_001852077.1. NC_010612.1.

    Genome annotation databases

    EnsemblBacteriaiACC42222; ACC42222; MMAR_3812.
    GeneIDi6228086.
    KEGGimmi:MMAR_3812.
    PATRICi18068817. VBIMycMar75906_4083.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000854 Genomic DNA. Translation: ACC42222.1 .
    RefSeqi WP_012395412.1. NC_010612.1.
    YP_001852077.1. NC_010612.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216594.MMAR_3812.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC42222 ; ACC42222 ; MMAR_3812 .
    GeneIDi 6228086.
    KEGGi mmi:MMAR_3812.
    PATRICi 18068817. VBIMycMar75906_4083.

    Phylogenomic databases

    eggNOGi COG0266.
    HOGENOMi HOG000020880.
    KOi K05522.
    OMAi NVYRAEV.
    OrthoDBi EOG6QP131.

    Enzyme and pathway databases

    BioCyci MMAR216594:GJOB-3837-MONOMER.

    Family and domain databases

    InterProi IPR015886. DNA_glyclase/AP_lyase_DNA-bd.
    IPR015887. DNA_glyclase_Znf_dom_DNA_BS.
    IPR012319. DNA_glycosylase/AP_lyase_cat.
    IPR010979. Ribosomal_S13-like_H2TH.
    IPR000214. Znf_DNA_glyclase/AP_lyase.
    IPR010663. Znf_DNA_glyclase/IsotRNA_synth.
    [Graphical view ]
    Pfami PF01149. Fapy_DNA_glyco. 1 hit.
    PF06831. H2TH. 1 hit.
    PF06827. zf-FPG_IleRS. 1 hit.
    [Graphical view ]
    SMARTi SM00898. Fapy_DNA_glyco. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46946. SSF46946. 1 hit.
    SSF81624. SSF81624. 1 hit.
    PROSITEi PS01242. ZF_FPG_1. 1 hit.
    PS51066. ZF_FPG_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-535 / MImported.

    Entry informationi

    Entry nameiB2HNG9_MYCMM
    AccessioniPrimary (citable) accession number: B2HNG9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 10, 2008
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzymeSAAS annotation, Reference proteomeImported

    External Data

    Dasty 3