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Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.UniRule annotation
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciMMAR216594:GJOB-2209-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrRUniRule annotation
Including the following 2 domains:
Pyrimidine operon regulatory proteinUniRule annotation
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Short name:
UPRTaseUniRule annotation
Gene namesi
Name:pyrRUniRule annotation
Ordered Locus Names:MMAR_2194
OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
Taxonomic identifieri216594 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000001190 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 187187Bifunctional protein PyrRPRO_1000139202Add
BLAST

Proteomic databases

PRIDEiB2HNE5.

Interactioni

Protein-protein interaction databases

STRINGi216594.MMAR_2194.

Structurei

3D structure databases

ProteinModelPortaliB2HNE5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi109 – 12113PRPP-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UK1. Bacteria.
COG2065. LUCA.
HOGENOMiHOG000245770.
KOiK02825.
OMAiVPTSRKE.
OrthoDBiEOG61VZD8.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

B2HNE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAANDAVDG RELMSAADVG RTISRIAHQI IEKTALDSPD SPRVVLLGIP
60 70 80 90 100
TRGVILASRL AANIGEYSGI EVDHGALDIT LYRDDLMSKP PRPLEETEIP
110 120 130 140 150
AGGVDDALVI LVDDVLYSGR SVRSALDALR DVGRPRSVQL AVLVDRGHRE
160 170 180
LPVRADYVGK NVPTARSESV HVQFSEHDGH DGVVISR
Length:187
Mass (Da):20,087
Last modified:June 10, 2008 - v1
Checksum:iA96443A405F995CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC40643.1.
RefSeqiWP_012393958.1. NC_010612.1.

Genome annotation databases

EnsemblBacteriaiACC40643; ACC40643; MMAR_2194.
KEGGimmi:MMAR_2194.
PATRICi18065327. VBIMycMar75906_2345.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA. Translation: ACC40643.1.
RefSeqiWP_012393958.1. NC_010612.1.

3D structure databases

ProteinModelPortaliB2HNE5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216594.MMAR_2194.

Proteomic databases

PRIDEiB2HNE5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACC40643; ACC40643; MMAR_2194.
KEGGimmi:MMAR_2194.
PATRICi18065327. VBIMycMar75906_2345.

Phylogenomic databases

eggNOGiENOG4108UK1. Bacteria.
COG2065. LUCA.
HOGENOMiHOG000245770.
KOiK02825.
OMAiVPTSRKE.
OrthoDBiEOG61VZD8.

Enzyme and pathway databases

BioCyciMMAR216594:GJOB-2209-MONOMER.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-535 / M.

Entry informationi

Entry nameiPYRR_MYCMM
AccessioniPrimary (citable) accession number: B2HNE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: November 11, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.