B2HN70 (B2HN70_MYCMM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
4-aminobutyrate aminotransferase GabT EMBL ACC40568.1

Gene names

Name:	gabT EMBL ACC40568.1
Ordered Locus Names:	MMAR_2118

Organism

Mycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]

Taxonomic identifier

216594 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. RuleBase RU003560

Ontologies

Keywords
Ligand	Pyridoxal phosphate RuleBase RU003560
Molecular function	Aminotransferase EMBL ACC40568.1 Transferase
Technical term	3D-structure PDB 3R4T Complete proteome
Gene Ontology (GO)
Biological process	gamma-aminobutyric acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	4-aminobutyrate transaminase activity Inferred from electronic annotation. Source: InterPro pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B2HN70 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 504CD1ABBE38B203	FASTA	446	47,210
	10 20 30 40 50 60 MASLDQSRLL VTEIPGPASL ELNKRRAAAV SGGVGVTLPV FVVRAGGGIV EDADGNRLID 70 80 90 100 110 120 LGSGIAVTTI GNSAPRVVDA VRDQVEQFTH TCFMVTPYEQ YVAVAEQLNR ITPGSGEKRT 130 140 150 160 170 180 VLFNSGAEAV ENSIKVARAH TRKQAVVAFD YAYHGRTNLT MALTAKSMPY KSGFGPFAPE 190 200 210 220 230 240 IYRAPVSYPY RDNLLDKDIA TDGELAAERA INLIDKQIGA ANLAAVIIEP IAGEGGFIVP 250 260 270 280 290 300 ADGFLPALQR WCRDNDVVFI ADEVQTGFAR TGAMFACDHE NVEPDLIVTA KGIADGFPLS 310 320 330 340 350 360 AVTGRAEIMD APHTSGLGGT FGGNPVACAA ALATIETIER DGMVERARQI ERLVMDRLLR 370 380 390 400 410 420 LQAADDRLGD VRGRGAMIAM ELVKSGTAEP DAALTQKLAA AAHAAGVIVL TCGMFGNVIR 430 440 LLPPLTISDE LLSEGLDILC QILADL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis." Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K., Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C., Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K., Lord A., Moule S. , Mungall K., Norbertczak H., Quail M.A., Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R., Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T. Genome Res. 18:729-741(2008) [PubMed: 18403782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Crystal structure of 4-aminobutyrate aminotransferase GabT from Mycobacterium marinum covalently bound to pyridoxal phosphate." Seattle Structural Genomics Center for Infectious Disease (SSGCID) Edwards T.E., Gardberg A.S., Sankaran B. Submitted (MAR-2011) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 2-445.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

CP000854 Genomic DNA. Translation: ACC40568.1.

RefSeq

YP_001850423.1. NC_010612.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3R4T	X-ray	2.50	A	2-445	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

B2HN70.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBMYCT00000032265; EBMYCP00000030705; EBMYCG00000032260.

GeneID

6226383.

GenomeReviews

Gene locus MMAR_2118 in contig CP000854_GR.

KEGG

mmi:MMAR_2118.

PATRIC

18065161. VBIMycMar75906_2262.

Organism-specific databases

CMR

Search...

Phylogenomic databases

GeneTree

EBGT00050000015339.

HOGENOM

HBG725944.

OMA

WDKEGRR.

ProtClustDB

PRK06058.

Family and domain databases

InterPro

IPR004632. 4NH2But_aminotransferase_bac.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]

Gene3D

G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.

KO

K07250.

PANTHER

PTHR11986. Aminotrans_3. 1 hit.

Pfam

PF00202. Aminotran_3. 1 hit.
[Graphical view]

SUPFAM

SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.

TIGRFAMs

TIGR00700. GABAtrnsam. 1 hit.

PROSITE

PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

B2HN70_MYCMM

Accession

Primary (citable) accession number: B2HN70

Entry history

Integrated into UniProtKB/TrEMBL:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)