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B2HMW0 (B2HMW0_MYCMM) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroxy-acid dehydratase HAMAP MF_00012
Short name=DAD HAMAP MF_00012
EC=4.2.1.9 HAMAP MF_00012
Gene names
Name:ilvD HAMAP MF_00012 EMBL ACC38899.1
Ordered Locus Names:MMAR_0432
OrganismMycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]
Taxonomic identifier216594 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length564 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP MF_00012

Cofactor

Binds 1 4Fe-4S cluster By similarity. HAMAP MF_00012

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP MF_00012

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP MF_00012

Sequence similarities

Belongs to the IlvD/Edd family. HAMAP MF_00012

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding1261Iron-sulfur (4Fe-4S) By similarity HAMAP MF_00012
Metal binding2031Iron-sulfur (4Fe-4S) By similarity HAMAP MF_00012

Sequences

Sequence LengthMass (Da)Tools
B2HMW0 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 2D498A508121D57B

FASTA56458,602
        10         20         30         40         50         60 
MPEADIKPRS RDVTDGLEKA AARGMLRAVG MVDEDFAKAQ IGVASSWNEI TPCNLSLDRL 

        70         80         90        100        110        120 
AKSVKEGVFA AGGYPLEFGT ISVSDGISMG HEGMHFSLVS REVIADSVET VMQAERLDGS 

       130        140        150        160        170        180 
VLLAGCDKSL PGMLMAAARL DLASVFLYAG SILPGVAKLS DGSEREVTII DAFEAVGACS 

       190        200        210        220        230        240 
RGLMSRADVD AIERAICPGE GACGGMYTAN TMASAAEALG MSLPGSAAPP ATDRRRDGFA 

       250        260        270        280        290        300 
RQSGQAVIEL LRQGITARDI MTREAFENAI AVVMAFGGST NAVLHLLAIA HEANVELTLD 

       310        320        330        340        350        360 
DFSRIGSKVP HLADVKPFGR HVMSHVDHIG GVPVVMKTLL DAGLLHGDCL TVTGRTVAEN 

       370        380        390        400        410        420 
LEAIAPPDPD GKVLRALNNP IHATGGITIL RGSLAPEGAV VKTAGLDTDV FEGTARVFDG 

       430        440        450        460        470        480 
ERAALDALED GTITHGDVVV IRYEGPKGGP GMREMLAITG AIKGAGLGKD VLLLTDGRFS 

       490        500        510        520        530        540 
GGTTGFCVGH IAPEAVDAGP IAFVRDGDRI RLDVAGRTLD VLTDPAEFAA RQQNFTPPAP 

       550        560 
RYKTGVLAKY VKLVGSAAIG AVCG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000854 Genomic DNA. Translation: ACC38899.1.
RefSeqYP_001848754.1. NC_010612.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB2HMW0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000032111; EBMYCP00000030551; EBMYCG00000032106.
GeneID6224680.
GenomeReviewsGene locus MMAR_0432 in contig CP000854_GR.
KEGGmmi:MMAR_0432.
PATRIC18061561. VBIMycMar75906_0474.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016366.
HOGENOMHBG671001.
OMANMPGAMI.
ProtClustDBPRK00911.

Family and domain databases

HAMAPMF_00012. IlvD.
[Tree]
InterProIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
KOK01687.
PANTHERPTHR21000. ILVD_EDD_family. 1 hit.
PfamPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
TIGRFAMsTIGR00110. IlvD. 1 hit.
PROSITEPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB2HMW0_MYCMM
AccessionPrimary (citable) accession number: B2HMW0
Entry history
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info