ID   B2HMT7_MYCMM            Unreviewed;       549 AA.
AC   B2HMT7;
DT   10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT   10-JUN-2008, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   SubName: Full=Fatty-acid-CoA ligase FadD5 {ECO:0000313|EMBL:ACC38876.1};
GN   Name=fadD5 {ECO:0000313|EMBL:ACC38876.1};
GN   OrderedLocusNames=MMAR_0409 {ECO:0000313|EMBL:ACC38876.1};
OS   Mycobacterium marinum (strain ATCC BAA-535 / M).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium ulcerans group.
OX   NCBI_TaxID=216594 {ECO:0000313|EMBL:ACC38876.1, ECO:0000313|Proteomes:UP000001190};
RN   [1] {ECO:0000313|EMBL:ACC38876.1, ECO:0000313|Proteomes:UP000001190}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-535 / M {ECO:0000313|Proteomes:UP000001190};
RX   PubMed=18403782; DOI=10.1101/gr.075069.107;
RA   Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA   Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA   Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA   Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA   Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA   Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT   "Insights from the complete genome sequence of Mycobacterium marinum on the
RT   evolution of Mycobacterium tuberculosis.";
RL   Genome Res. 18:729-741(2008).
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DR   EMBL; CP000854; ACC38876.1; -; Genomic_DNA.
DR   RefSeq; WP_012392388.1; NC_010612.1.
DR   AlphaFoldDB; B2HMT7; -.
DR   STRING; 216594.MMAR_0409; -.
DR   KEGG; mmi:MMAR_0409; -.
DR   eggNOG; COG0318; Bacteria.
DR   HOGENOM; CLU_000022_59_0_11; -.
DR   OrthoDB; 9803968at2; -.
DR   Proteomes; UP000001190; Chromosome.
DR   GO; GO:0016877; F:ligase activity, forming carbon-sulfur bonds; IEA:UniProt.
DR   CDD; cd17631; FACL_FadD13-like; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43767; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR   PANTHER; PTHR43767:SF1; NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:ACC38876.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001190}.
FT   DOMAIN          31..394
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          444..518
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   549 AA;  59547 MW;  68D233C97D0509EF CRC64;
     MTAELASHLP QAAHALEQPY LARRQNWVNQ LERHAMMQPR ATAIRYLGHT VTWADLRYRV
     AALAGSLSRR GVGFGDRVMI LMLNRTEFVE SVLAANMLGA IAVPLNFRLT PSEIAFLVED
     CAPRLVITEE VLAQVAVGVR EIAPALSTIV VAGGASDPTV VGYDELISET GDPPEPVDIP
     NDSPALIMYT SGTTGRPKGA VLTHTNLTGQ VMTALYTGGA NINSDVGFIG VPFFHIAGIG
     NMLSGMLLGV PTVIYPLGAF NPGQLLDVLE AERVSGIFLV PAQWQAVCAE QQARPRELSL
     RVMSWGAAPA PDALLRQMSE VFPGTQIMAA FGQTEMSPVT CMLLGEDAIR KRGSVGKVIP
     TVSARVVDDE MNDVPIGQVG EIVYRAPTLM SGYWNNPDAT AEAFAGGWFH SGDLVRMDED
     GYVWVVDRKK DMIISGGENV YCAEVENVLA SHPSIVEVAV IGRADEKWGE VPIAVAAVTK
     DHLRIEDLDE YLTERLARYK HPKALEIVDA LPRNPSGKVL KTELRLRYGV GVYSESRSVS
     RSFEFREGS
//