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Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate 5-kinase (proB)
  2. Gamma-glutamyl phosphate reductase (proA)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Proline biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00098; UER00360

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
Short name:
GSA dehydrogenaseUniRule annotation
Gene namesi
Name:proAUniRule annotation
Ordered Locus Names:MMAR_3753
OrganismiMycobacterium marinum (strain ATCC BAA-535 / M)
Taxonomic identifieri216594 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000001190 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001936281 – 423Gamma-glutamyl phosphate reductaseAdd BLAST423

Interactioni

Protein-protein interaction databases

STRINGi216594.MMAR_3753

Structurei

3D structure databases

ProteinModelPortaliB2HME9
SMRiB2HME9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C2S Bacteria
COG0014 LUCA
HOGENOMiHOG000246356
KOiK00147
OMAiHGSHHTD
OrthoDBiPOG091H00OT

Family and domain databases

CDDicd07079 ALDH_F18-19_ProA-GPR, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
HAMAPiMF_00412 ProA, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR020593 G-glutamylP_reductase_CS
IPR012134 Glu-5-SA_DH
IPR000965 GPR_dom
PfamiView protein in Pfam
PF00171 Aldedh, 2 hits
PIRSFiPIRSF000151 GPR, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00407 proA, 1 hit
PROSITEiView protein in PROSITE
PS01223 PROA, 1 hit

Sequencei

Sequence statusi: Complete.

B2HME9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLQAAPRSA AAQQREPDLR QEVHDAARRA RVAARLLAVV PTGVKDRALH
60 70 80 90 100
AAADAILAHV DRILSANAED LDAARAADTP AAMLDRLALN PQRVDGIAAG
110 120 130 140 150
LRQVAGLPDP VGEVLRGYTL PNGLQLRQQR VPLGVVGMIY EGRPNVTVDA
160 170 180 190 200
FGLTLKSGNA ALLRGSSSAA RSNEALVNVL RSALDSEQLP ADAVQLLSSA
210 220 230 240 250
DRSTVTHLIQ ARGLVDVAIP RGGAGLIDAV VRDAQVPTIE TGVGNCHVYV
260 270 280 290 300
HEAADLDVAE RILLNSKTRR PSVCNAAETL LVDAAIAEHA MPRLIGALQD
310 320 330 340 350
AGVTVHLDAD EQDLRREYLA MEIAVAVVDG VDGAIAHINE YGTGHTEAIV
360 370 380 390 400
TTNLAAAQRF TERIDAAAVM VNASTAFTDG EQFGFGAEIG ISTQKLHARG
410 420
PMGLPELTST KWIVWGEGHT RPA
Length:423
Mass (Da):44,566
Last modified:June 10, 2008 - v1
Checksum:i2E710B12F6BCE85B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000854 Genomic DNA Translation: ACC42169.1
RefSeqiWP_012395362.1, NC_010612.1

Genome annotation databases

EnsemblBacteriaiACC42169; ACC42169; MMAR_3753
KEGGimmi:MMAR_3753

Similar proteinsi

Entry informationi

Entry nameiPROA_MYCMM
AccessioniPrimary (citable) accession number: B2HME9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health