B2HLJ8 (PATR_MYCMM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative phenylalanine aminotransferase
EC=2.6.1.-

Gene names

Name:	pat
Ordered Locus Names:	MMAR_5326

Organism

Mycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]

Taxonomic identifier

216594 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May catalyze the transamination reaction in phenylalanine biosynthesis By similarity. HAMAP MF_01513
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01513
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: InterPro pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Putative phenylalanine aminotransferase HAMAP MF_01513		PRO_1000146151
Amino acid modifications
	Modified residue	221	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2HLJ8 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 8D5F4DA7697BF0C3	FASTA	361	38,523
	10 20 30 40 50 60 MTARLRPVLA GLPVYVPGKT VPGAIKLASN ETVFGPLPSV RAAIEHATQS INRYPDNGCL 70 80 90 100 110 120 AVKAALARHV SSLSAADFGP EHIAVGCGSV SLCQQLVQIT ASVGDEVIFG WRSFELYPPQ 130 140 150 160 170 180 VQVAGATAIQ VPLTNHTFDL EAMLAAVTER TRLIIVCNPN NPTSTVVQPE ALAEFVRSVP 190 200 210 220 230 240 PHILVAIDEA YVEYLRDGTV PDSPHLVRTH SNVVVLRTFS KAYGLAGLRV GYAVGQPDVI 250 260 270 280 290 300 AALDKVYVPF TVSSLAQAAA IASVQAADEL LARTDAVVAE RGRVSAELRA AGFTVPPSQA 310 320 330 340 350 360 NFVWLPLEDR TTDFVTQAAK AHIVVRPYGA DGVRVTIAAP EENDALLRFA RCWITHRDGA R

References

[1]

"Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis." Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K., Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C., Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K., Lord A., Moule S. , Mungall K., Norbertczak H., Quail M.A., Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R., Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T. Genome Res. 18:729-741(2008) [PubMed: 18403782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-535 / M.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000854 Genomic DNA. Translation: ACC43730.1.
RefSeq	YP_001853585.1. NC_010612.1.
3D structure databases
ProteinModelPortal	B2HLJ8.
ModBase	Search...
Protein-protein interaction databases
STRING	B2HLJ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000035834; EBMYCP00000034274; EBMYCG00000035829.
GeneID	6229624.
GenomeReviews	Gene locus MMAR_5326 in contig CP000854_GR.
KEGG	mmi:MMAR_5326.
PATRIC	18072121. VBIMycMar75906_5710.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00070000031717.
HOGENOM	HBG646350.
OMA	NNTKIVW.
ProtClustDB	PRK03321.
Family and domain databases
HAMAP	MF_01513. Phe_aminotrans_2. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR024892. AroT. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PATR_MYCMM

Accession

Primary (citable) accession number: B2HLJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	June 10, 2008
Last modified:	January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program