B2HKZ1 (B2HKZ1_MYCMM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Dihydrodipicolinate synthase DapA EMBL ACC40412.1

Gene names

Name:	dapA EMBL ACC40412.1
Ordered Locus Names:	MMAR_1962

Organism

Mycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]

Taxonomic identifier

216594 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. SAAS SAAS005263
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. SAAS SAAS005263
Subcellular location	Cytoplasm By similarity SAAS SAAS005263.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis SAAS SAAS005263 Lysine biosynthesis SAAS SAAS005263
Cellular component	Cytoplasm SAAS SAAS005263
Ligand	Schiff base SAAS SAAS005263
Molecular function	Lyase SAAS SAAS005263
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	dihydrodipicolinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B2HKZ1 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 73D03F764F664192	FASTA	300	30,738
	10 20 30 40 50 60 MSTVGFDVPA RLGTLLTAMV TPFGSDGALD LAAAARLANH LVDQGCDGLV VSGTTGESPT 70 80 90 100 110 120 TTDDEKRELL RVVLEAVGDR ARVIAGAGTN DTAHSIGLAK AAAAEGAHGL LVVTPYYSKP 130 140 150 160 170 180 PQSGLLAHFT AVADATELPV LLYDIPGRSA VPIESETIRA LAKHPNIVGV KDAKADLPSG 190 200 210 220 230 240 AQIMADTGLA YYSGDDALNL PWLAMGAIGF ISVIGHLAAG QLREMLSAFS SGDVATARKI 250 260 270 280 290 300 NVAVSPLCNA MTRLGGVTLS KAGLRLQGIE VGDPRLPQVA ATAEQIDVLA ADMRAASVLR

References

[1]

"Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis." Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K., Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C., Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K., Lord A., Moule S. , Mungall K., Norbertczak H., Quail M.A., Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R., Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T. Genome Res. 18:729-741(2008) [PubMed: 18403782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000854 Genomic DNA. Translation: ACC40412.1.
RefSeq	YP_001850267.1. NC_010612.1.
3D structure databases
ProteinModelPortal	B2HKZ1.
SMR	B2HKZ1. Positions 5-300.
ModBase	Search...
Protein-protein interaction databases
STRING	B2HKZ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000036000; EBMYCP00000034440; EBMYCG00000035995.
GeneID	6226222.
GenomeReviews	Gene locus MMAR_1962 in contig CP000854_GR.
KEGG	mmi:MMAR_1962.
PATRIC	18064823. VBIMycMar75906_2096.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016215.
HOGENOM	HBG358848.
OMA	HGCISVV.
ProtClustDB	PRK03170.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR002220. Dihydrodipicolinate_synth-like. IPR020625. Dihydrodipicolinate_synth_AS. IPR020624. Dihydrodipicolinate_synth_CS. IPR005263. Dihydrodipicolinate_synth_DapA. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01714.
PANTHER	PTHR12128. DHDPS. 1 hit.
Pfam	PF00701. DHDPS. 1 hit. [Graphical view]
PIRSF	PIRSF001365. DHDPS. 1 hit.
PRINTS	PR00146. DHPICSNTHASE.
TIGRFAMs	TIGR00674. DapA. 1 hit.
PROSITE	PS00665. DHDPS_1. 1 hit. PS00666. DHDPS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B2HKZ1_MYCMM

Accession

Primary (citable) accession number: B2HKZ1

Entry history

Integrated into UniProtKB/TrEMBL:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)