B2HKV6 (B2HKV6_MYCMM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Alanine dehydrogenase PIRNR PIRNR000183
EC=1.4.1.1 PIRNR PIRNR000183

Gene names

Name:	ald EMBL ACC40377.1
Ordered Locus Names:	MMAR_1928

Organism

Mycobacterium marinum (strain ATCC BAA-535 / M) [Complete proteome] [HAMAP]

Taxonomic identifier

216594 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH. PIRNR PIRNR000183
Pathway	Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1. PIRNR PIRNR000183
Sequence similarities	Belongs to the AlaDH/PNT family. PIRNR PIRNR000183

Ontologies

Keywords
Ligand	NAD PIRNR PIRNR000183
Molecular function	Oxidoreductase PIRNR PIRNR000183
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	alanine dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B2HKV6 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 9A86084FE9EB8B7B	FASTA	371	38,636
	10 20 30 40 50 60 MRVGIPTETK DNEFRVAITP AGVAALTKRG HEVLIQAGAG EGSAISDSDF KAAGAQLIST 70 80 90 100 110 120 ADQVWADADL LLKVKEPIES EYGRLRRGQT LFTYLHLAAS RPCTDALLKS GTTSIAYETV 130 140 150 160 170 180 QTADGALPLL APMSEVAGRL SAQAGAYHLM RTHGGRGVLM GGVPGVKPAD VVVIGAGTAG 190 200 210 220 230 240 YNAARVANGM GAMVTVLDVN INKLRQIDAE FGGRVRTRYS STLDLEDAAV NADLLIGAVL 250 260 270 280 290 300 VPGAKAPKLI PNSLVARMKK GAVLVDISID QGGCFEDSRP TTHTSPTFTV HDTVFYCVAN 310 320 330 340 350 360 MPGAAPRTST YALTNATMPY VLKLADLGWQ AACLSDSALA KGLSTHEGAL LADHVAADLD 370 LPFTDPANVL G

References

[1]

"Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis." Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K., Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C., Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K., Lord A., Moule S. , Mungall K., Norbertczak H., Quail M.A., Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R., Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T. Genome Res. 18:729-741(2008) [PubMed: 18403782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000854 Genomic DNA. Translation: ACC40377.1.
RefSeq	YP_001850232.1. NC_010612.1.
3D structure databases
ProteinModelPortal	B2HKV6.
ModBase	Search...
Protein-protein interaction databases
STRING	B2HKV6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000033485; EBMYCP00000031925; EBMYCG00000033480.
GeneID	6226187.
GenomeReviews	Gene locus MMAR_1928 in contig CP000854_GR.
KEGG	mmi:MMAR_1928.
PATRIC	18064757. VBIMycMar75906_2063.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016024.
HOGENOM	HBG289735.
OMA	VAHGHEV.
ProtClustDB	CLSK792072.
Family and domain databases
InterPro	IPR008142. Ala_DH/PNT_CS1. IPR008143. Ala_DH/PNT_CS2. IPR008141. Ala_DH/Pyr_transHydgase. IPR007886. AlaDH/PNT_N. IPR007698. AlaDH/PNT_NAD(H)-bd. [Graphical view]
KO	K00259.
PANTHER	PTHR10160:SF3. PTHR10160:SF3. 1 hit.
Pfam	PF01262. AlaDh_PNT_C. 1 hit. PF05222. AlaDh_PNT_N. 1 hit. [Graphical view]
PIRSF	PIRSF000183. Alanine_dh. 1 hit.
SMART	SM01002. AlaDh_PNT_C. 1 hit. SM01003. AlaDh_PNT_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00518. AlaDH. 1 hit.
PROSITE	PS00836. ALADH_PNT_1. 1 hit. PS00837. ALADH_PNT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B2HKV6_MYCMM

Accession

Primary (citable) accession number: B2HKV6

Entry history

Integrated into UniProtKB/TrEMBL:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)